Purpose
Your body is like a tapestry made of trillions of cells, which are organized to form its structure and carryout many critical functions necessary for daily living. Healthy and properly functioning cells are necessary for maintaining good health.
Daily, your body's cells are either dying or replicating into new cells. This is a normal physiological process that occurs naturally and happens without your having to think about it. Normal cell-to-cell communication is also necessary for the development of new cells and for the maintenance of healthy cells. This function must be properly maintained for the replication of healthy cell structures and to achieve optimal health.
The body is bombarded by damaging free radicals and toxins, which can disrupt the process of creating new cells and their typical functions. The generation of free radicals is a consequence of normal processes (metabolism) within the body and cannot be avoided. To some extent free radicals are necessary and part of normal physiological processes.
In today's environment, the body is bombarded by an exceptionally high amount of toxins and other cell disruptors like free radicals, which if not kept in check, can have a negative impact on health.
Without adequate protection, the number of toxins and free radicals outnumber the body's ability to adequately fight them. This puts the body into oxidative stress and toxic overload. Oxidative stress creates damage to lipids, proteins and DNA. These factors contribute to aging and to the development of many age-related conditions (Lobo, Patil, Phatak, & Chandra, 2010).
The body has its own built-in (endogenous) antioxidant systems, which fight free radicals and toxins every single day. Antioxidants neutralize free radicals rendering them harmless. GSH and SOD are two of these internal systems.
Furthermore, antioxidants with the ability to neutralize and prevent the damaging effects of free radicals are obtained through the diet (exogenous). An individual's ability to fight free radicals can be achieved through eating a variety of fruits and vegetables as well as by taking scientifically created nutritional supplements like PurXcel.
PurXcel offers a comprehensive blend of antioxidants important for neutralizing a variety of different types free radicals and for offering detoxification support. Primary contributors in this product include proprietary forms of glutathione (GSH), superoxide dismutase (SOD) and aloe polymannose. These ingredients have clinically demonstrated significant improvements in overall health. 1
Glutathione (GSH)
GSH is necessary for the defense and maintenance of healthy cells and their functions. It serves a protective role in its ability to neutralize cell damaging free radicals and assists with the removal of toxins within cells (Forman, Zhang, & Rinna, 2009).
Until recent advances, most dietary forms of glutathione are broken down in the digestive system making them incapable of being absorbed in the blood and cells of the body. PurXcel utilizes a proprietary form of glutathione, which has been shown in clinical trial to significantly increase GSH within the blood and specific immune cells (Richie, et al., 2015).1
Superoxide Dismutase (SOD)
SOD is an enzyme found in every cell of the body. It is an internal antioxidant defense mechanism, which helps keep oxidative stress at bay.
In clinical trial, superoxide dismutase ingredient brand named SOD B Etramel® established improvements in perceived stress, physical and mental fatigue and an overall improvement in the quality of life (Carillon, Notin, Schmitt, Simoneau, & Lacan, 2014).1
Aloe Vera
The leaf of the Aloe vera plant contains phytonutrients with known antioxidant and other health-promoting properties. This plant has been used for centuries for its therapeutic properties. It supports a healthy inflammatory response thereby extending support to the immune system (Nejatzadeh-Barandozi, 2013).
PurXcel uses an exclusive and proprietary form of aloe known (BioAloe®) to have polymannose, a unique polysaccharide. In clinical trial, this ingredient when combined with other ingredients demonstrated cognitive function support (Martin, et al., 2017).1
Synergistic Ingredients
Vitamin C
This essential (meaning it must be obtained through diet or supplements) nutrient acts as powerful antioxidant and it helps regenerate vitamin E prolonging its protective effects. Supports the immune system (Oregon State University, Linus Pauling Institute, 2019).1
Vitamin E
An essential nutrient that can halt further generation of free radical chain reactions. This fat-soluble vitamin is especially helpful in fighting oxidation (damage caused by free radicals) of fats like LDL cholesterol (Oregon State University, Linus Pauling Institute, 2019).1
Selenium
An essential nutrient necessary to produce GSH in the body. In this way, it supports the body's own protective antioxidant system (Oregon State University, Linus Pauling Institute, 2019).1
N-acetyl L-cysteine (NAC)
NAC is a precursor to the body's production of glutathione. Supports detoxification and neutralization of free radicals [antioxidant] (Dean, Giorlando, & Berk, 2011).
Alpha Lipoic Acid
An ingredient with the ability to directly fight damaging free radicals. It helps with the regeneration of other antioxidants like vitamins C & E and glutathione (Oregon State University, Linus Pauling Institute, 2019). It has been shown to especially help protect nerve tissues (Rochette, Ghibu, Richard, Zeller, & Cottin, 2013).1
Moringa oleifera
Moringa oleifera has immune, antioxidant and liver protective properties. In addition to promoting and maintaining a healthy inflammatory response, this unique ingredient supports liver function, which is vital to the body's detoxification processes (Anwar, Latif, Ashraf, & Gilani, 2007).
Turmeric
Curcumin obtained from turmeric spice has antioxidant and neuroprotective properties. It also helps maintain a healthy inflammatory response within the body (Oregon State University, Linus Pauling Institute, 2019).1
Broccoli (sulforaphane)
This sulfur containing vegetable contains unique phytonutrients like sulforaphane. This phytonutrient assists in the release of Nrf2, which participates in the neutralization of free radicals, liver detoxification processes and supports a healthy inflammatory response (Oregon State University, Linus Pauling Institute, 2019).1
Cordyceps sinensis
A mushroom-like substance, cordyceps has been used traditionally for thousands of years as a tonic for cardiovascular, immune and respiratory support. Certain components in cordyceps have antioxidant and immunological actions (Tuli, Sandhu, & Sharma, 2014).1
Milk Thistle
Silymarin, a compound of milk thistle, has been shown to have hepatoprotection (liver), immune supporting and free radical neutralization properties. It may help by supporting the cell membrane's functions of keeping toxins from entering and shuttling them out (Post-White, Ladas, & Kelly, 2007).1
Blueberry
Blueberries contain flavonoid compounds with free radical scavenging benefits to the brain and immune modulating effects to help maintain a healthy immune system. These properties suggest it may support a healthy inflammatory response and have neuroprotective properties (Spencer, 2010).1
Schisandra
This herb has been used to help maintain liver function. Certain constituents of Schisandra have immune supporting properties by helping with the maintenance of healthy inflammatory responses (Oh, et al., 2010).1
Grape seed extract
This phytonutrient is rich in antioxidant compounds known as flavonoids. These powerful phytonutrients have been shown to be especially protective of the cardiovascular system (Oregon State University, Linus Pauling Institute, 2019).1
Pomegranate
This fruit contains potent antioxidant compounds. These phytonutrients support a healthy inflammatory response, especially in the gastrointestinal tract (Colombo, Sangiovanni, & Agli, 2013). Pomegranate's antioxidant protection extends to the cardiovascular system by minimizing oxidized LDL cholesterol (Fuhrman, Volkova, & Aviram, 2005).1
BioPerine® (black pepper extract)
This proprietary form of black pepper can help improve the absorption of various ingredients and nutrients. It being added to a nutritional supplement can assist in the body's absorption of ingredients combined with it in the gastrointestinal tract (Majeed & Prakash, 2007).1
References
Anwar, F., Latif, S., Ashraf, M., & Gilani, A. H. (2007). Moringa oleifera: A Food Plant with Multiple Medicinal Uses. Phytother. Res., 17 - 25.
Carillon, J., Notin, C., Schmitt, K., Simoneau, G., & Lacan, D. (2014). Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients, 6, 2348-2359.
Colombo, E., Sangiovanni, E., & Agli, a. M. (2013). A Review on the Anti-Inflammatory Activity of Pomegranate in the GI tract. Evidence-Based Complementary and Alternative Medicine, 247145, 1 - 11.
Dean, O., Giorlando, F., & Berk, M. (2011). N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. J Psych Neuroscience, 36(2): 78–86.
Forman, H. J., Zhang, H., & Rinna, A. (2009). Glutathione: Overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med, 30(1-2): 1–12.
Fuhrman, B., Volkova, N., & Aviram, M. (2005). Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages. J Nutr Biochem, 16, 570 - 576 .
Lewisa, J. E., McDaniel, H. R., Agroninc, M. E., Loewensteina, D. A., Riverosc, J., Mestrec, R., . . . Alie, K. H. (2013). The Effect of an Aloe Polymannose Multinutrient Complex on Cognitive and Immune Functioning in Alzheimer's Disease. J Alzheimer Disease, vol. 33, no. 2, pp. 393-406.
Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy Review, 4(8): 118–126.
Majeed, M., & Prakash, L. (2007). Targeting Optimal Nutrient Absorption with Phytonutrients. East Windsor, NJ: Sabinsa Corporation.
Martin, A., Stillman, J., Miguez, M.-J., H. R., Konefal, J., Woolger, J. M., & Lewis, J. E. (2017). The effect of dietary supplementation on brain-derived neurotrophic factor and cognitive functioning in Alzheimer's dementia . Journal of Clinical and Translational Research, 3(3): 337 - 343.
Nejatzadeh-Barandozi, F. (2013). Antibacterial activities and antioxidant capacity of Aloe vera. Org Med Chem Letters, 3: 5.
Oh, S., Kim, Y., Bae, D., Um, B., Pan, C., Kim, C., . . . Lee, J. (2010). Anti-inflammatory effects of Gomisin N, Gosimin J and Schisandrin C Isolated from the fruit of Schisandra chinensis. Biosci Biotechnol Biochem, 74(2) 1 - 7.
Oregon State University, Linus Pauling Institute. (2019, June 25). Lipoic Acid; Vitamin C; Vitamin E; Selenium; Curcumin; Isothiocyanates; Flavonoids. Retrieved from Micronutrient Information Center: https://lpi.oregonstate.edu/mic/dietary-factors/lipoic-acid#unbound-lipoic-acid
Post-White, J., Ladas, E. J., & Kelly, K. M. (2007). Advances in the Use of Milk Thistle (Silybum marianum). Integr Cancer Therapies, 6(2): 104 - 109.
Richie, J., Nichenametla, S., Neidig, Calcagnotto, A., Haley, J., Schell, T., & Muscat, J. (2015). Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr, 54(2):251-63.
Rochette, L., Ghibu, S., Richard, C., Zeller, M., & Cottin, Y. (2013). Direct and indirect antioxidant properties of a-lipoic acid and therapeutic potential . Mol. Nutr. Food Res., 57, 114 - 125.
Spencer, J. P. (2010). The impact of fruit flavonoids on memory and cognition . British J Nutr, 104, S40 - S47.
Tuli, H. S., Sandhu, S. S., & Sharma, A. K. (2014). Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin. Biotech, 4:1 - 12.