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  • Generic Name: (interferon gamma-1b)
    Other Brands: N/A
  • Last Revised: 10/2015
    • What is this medication and its most common uses?

      Actimmune is a medicine used to reduce the frequency and severity of serious infections associated with chronic granulomatous disease (a genetic disorder that affects the functioning of some cells of the immune system). Actimmune is also used to slow the worsening of severe, malignant osteopetrosis (a genetic disorder that affects normal bone formation). Actimmune is injected subcutaneously (just below the skin).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Actimmune is a form of a protein called interferon gamma that is similar to a protein your body makes naturally. It has not yet been proven precisely how Actimmune works to successfully treat your condition.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Actimmune may help to lower the risk and severity of serious infections, and may also slow the worsening of osteopetrosis.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you use Actimmune exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may ask you series of questions from time to time that will help assess how well your condition is controlled with treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: fever, headache, rash, chills, redness or tenderness at the injection site, tiredness, diarrhea.

      Less common side effects may include:

      Nervous system effects, such as decreased mental status, problems with walking, or dizziness.

      Serious allergic reactions, with symptoms such as itching; rash; swelling of your face, eyes, lips, tongue, or throat; or trouble breathing.

      Actimmune may also cause low blood cell or platelet (a type of blood cell that forms clots to help stop bleeding) counts, kidney problems, or increased liver function tests.

    • Who should not take this medication?

      Do not use Actimmune if you are allergic to it, any of its ingredients, other types of interferon gamma proteins, or to Escherichia coli (a type of bacteria) derived products.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Actimmune. Also, talk to your healthcare provider about your complete medical history, especially if you have heart, liver, or kidney problems; seizures; if you are allergic to latex; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Chronic Granulomatous Disease

      Adults and children ≥1 year: Your healthcare provider will prescribe the appropriate dose for you or your child based on your condition.


      Adults and children ≥1 month: Your healthcare provider will prescribe the appropriate dose for you or your child based on your condition.

    • How should I take this medication?

      Use Actimmune exactly as prescribed by your healthcare provider. Do not use it more often or stop using it without first talking to your healthcare provider.

      Your healthcare provider may administer the first dose of Actimmune to you. Do not attempt to self-inject without proper training.

      If you experience flu-like symptoms, administering Actimmune at bedtime may reduce these side effects. Speak with your healthcare provider about appropriately using acetaminophen to reduce fever and headache.

      Please review the instructions that came with your prescription on how to properly use Actimmune.

    • What should I avoid while taking this medication?

      Do not shake Actimmune.

      Do not drive, operate heavy machinery, or do other dangerous activities until you know how Actimmune affects you.

      Do not mix Actimmune with other drugs in the same syringe.

    • What are the possible food and drug interactions associated with this medication?

      If Actimmune is used with certain other drugs, the effects of either could be increased, decreased, or altered. Actimmune may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Actimmune during pregnancy and breastfeeding are unknown. Do not breastfeed while you are using Actimmune. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Actimmune, use it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not use two doses at once.

    • How should I store this medication?

      Store in the refrigerator. Do not freeze.

      Unused vials of Actimmune can be stored at room temperature for up to 12 hours before using. Throw away if vials are not used within 12 hours. Do not return to the refrigerator.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.