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  • Generic Name: (cabozantinib)
    Other Brands: N/A
  • Last Revised: 06/2016
    • What is this medication and its most common uses?

      Cabometyx is a medicine used to treat people with advanced kidney cancer (renal cell carcinoma) whose cancer has spread or grown after treatment with other cancer medications.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Cabometyx works by slowing or stopping the growth and spread of tumors in the body.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: In a clinical study, people taking Cabometyx were less likely to experience tumor growth and spread and were more likely to live longer than those who were taking another medicine used for kidney cancer called everolimus.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Cabometyx exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: diarrhea, tiredness, nausea, decreased appetite, high blood pressure, vomiting, weight loss, constipation.

      Less common side effects may include:

      Severe bleeding (hemorrhage), with signs such as coughing up blood or blood clots, vomiting blood or your vomit looks like coffee-grounds, red or black (looks like tar) stools, menstrual bleeding that is heavier than normal, or any unusual or heavy bleeding.

      A tear in your stomach or intestinal wall or an abnormal connection between 2 parts of your body, with symptoms such as tenderness or pain in your stomach area.

      Blood clots, stroke, heart attack, and chest pain, with symptoms such as swelling or pain in your arms or legs; shortness of breath; feeling lightheaded or faint; sudden confusion; trouble speaking or understanding; sudden trouble seeing in one or both eyes; sweating more than usual; numbness or weakness of your face, arm, or leg, especially on one side of your body; sudden trouble walking; dizziness; loss of balance or coordination; or a sudden severe headache.

      A skin problem called hand-foot skin reaction, with symptoms such as rashes, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet.

      A condition called reversible posterior leukoencephalopathy syndrome, with symptoms such as headaches, seizures, confusion, changes in vision, or problems thinking.

      Harm to your unborn baby if taken during pregnancy. Contact your healthcare provider immediately if you believe or suspect you are pregnant while you are taking Cabometyx.

    • Who should not take this medication?

      Do not take Cabometyx if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Cabometyx. Also, talk to your healthcare provider about your complete medical history, especially if you have any unusual bleeding, high blood pressure, or liver problems; plan to have any surgery (including dental surgery); or are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is 60 milligrams a day. Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with Cabometyx if you have certain side effects.

      If you are taking certain other medicines or have liver problems, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Cabometyx exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Cabometyx without first talking to your healthcare provider.

      Do not take Cabometyx with food. Do not eat for at least 2 hours before and at least 1 hour after taking Cabometyx.

      Swallow Cabometyx tablets whole with a full glass (at least 8 ounces) of water.

      Do not crush Cabometyx tablets.

      If you are able to become pregnant, you should use effective birth control during treatment and for 4 months after your final dose of Cabometyx. Talk to your healthcare provider about birth control methods that may be right for you.

    • What should I avoid while taking this medication?

      Do not drink grapefruit juice, eat grapefruit, or take supplements that contain grapefruit during treatment with Cabometyx.

    • What are the possible food and drug interactions associated with this medication?

      If Cabometyx is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Cabometyx may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Cabometyx may harm your unborn baby if taken during pregnancy. The effects of Cabometyx during breastfeeding are unknown. Do not breastfeed during treatment and for 4 months after your final dose of Cabometyx. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Cabometyx and your next dose is in less than 12 hours, take your next dose at the normal time. Do not make up the missed dose. However, if your next dose is in 12 hours or more, take the missed dose as soon as you remember, then take your next dose at the normal time.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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