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  • Generic Name: (caffeine/ergotamine tartrate)
    Other Brands: N/A
  • Last Revised: 06/2014
    • What is this medication and its most common uses?

      Cafergot is a medicine used to treat or prevent migraine headaches. Cafergot contains two medicines that work in two different ways to help treat your headache: caffeine and ergotamine.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      A migraine occurs when swollen blood vessels in the brain press on nearby nerves. Cafergot works by narrowing those blood vessels, helping to improve your migraine symptoms.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Cafergot may help relieve your migraine headache.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Cafergot exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may feel a relief in your migraine headache after you take Cafergot . This is a good indicator that the medicine is working. Recording your headache frequency and medication use may be helpful to you and your healthcare provider in monitoring your progress.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Cafergot may cause serious and life-threatening blood vessel problems if taken with certain other medications (such as ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, and troleandomycin). Tell your healthcare provider right away if you develop symptoms such as muscle pains, numbness, coldness and paleness of your hands and feet. Also, talk to your healthcare provider about all the medicines you take before starting treatment with Cafergot.

      Side effects may include: nausea, vomiting, numbness, weakness, swelling, itching.

    • Who should not take this medication?

      Do not take Cafergot if you are allergic to it or any of its ingredients.

      Do not take Cafergot if you are taking the following medications: clarithromycin, erythromycin, indinavir, itraconazole, ketoconazole, nelfinavir, ritonavir, or troleandomycin.

      Do not take Cafergot if you have a history of heart problems, problems with your blood circulation, or narrowing of blood vessels to your legs, arms, or stomach.

      Do not take Cafergot if you have high blood pressure, kidney or liver impairment.

      Do not take Cafergot if you have sepsis (a bloodstream infection).

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Cafergot. Also, talk to your healthcare provider about your complete medical history, especially if you have heart or liver problems; high blood pressure; a family history of heart disease or stroke; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is two tablets at the first sign of a migraine attack. Take an additional tablet every 30 minutes, as needed. Do not take more than 6 tablets per migraine attack or 10 tablets per week.

    • How should I take this medication?

      Take Cafergot exactly as prescribed by your healthcare provider.

    • What should I avoid while taking this medication?

      Do not change your dose or take Cafergot more often without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Cafergot is used with certain other drugs, the effects of either could be increased, decreased, or altered. Cafergot may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Cafergot can harm your unborn baby if you take it during pregnancy. Do not take Cafergot if you are pregnant. Cafergot can be found in your breast milk if you take it while breastfeeding. Do not breastfeed while you are taking Cafergot. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Cafergot should be used only as needed for migraine attacks.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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