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  • Generic Name: (caffeine citrate)
    Other Brands: N/A
  • Last Revised: 06/2015
    • What is this medication and its most common uses?

      Caffeine citrate is a medicine used to treat apnea (short episodes of stopped breathing) of prematurity. Caffeine citrate is available as an oral solution. It is also available as an injection for hospital use.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Caffeine citrate may work in the breathing center and relax muscles in the airways to help improve breathing.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: In studies, more infants experienced zero apnea events on day 2 of treatment than infants who did not receive treatment.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions. It is important that you give caffeine citrate exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your child may experience an improvement in his/her condition. Your healthcare provider may also ask you questions to assess how well the condition is being treated.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: rash, feeding intolerance.

      Less common side effects may include:

      Caffeine citrate may increase heart rate.

    • Who should not take this medication?

      Do not give caffeine citrate if your child is allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with caffeine citrate. Also, talk to your healthcare provider about your complete medical history, especially if your child has seizure disorders; or kidney, liver, or heart problems.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Infants between 28-<33 weeks gestational age: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her weight.

    • How should I take this medication?

      Give caffeine citrate exactly as prescribed by your healthcare provider. Do not give it more often or stop giving it without first talking to your healthcare provider.

      Caffeine citrate oral solution does not contain any preservatives and each vial is for single use only. Throw away any unused portion of the medicine.

      It is important that the dose of the oral solution is measured accurately with an appropriate syringe.

      If your child is continuing to have apnea events, notify your healthcare provider.

      If your child begins to experience stomach problems, such as vomiting or bloody stools, or seems more tired, notify your healthcare provider.

      Please review the instructions that come with your prescription on how to properly use caffeine citrate.

    • What should I avoid while taking this medication?

      Do not use caffeine citrate oral solution that is discolored.

    • What are the possible food and drug interactions associated with this medication?

      If caffeine citrate is given with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining caffeine citrate with the following: cimetidine, ketoconazole, phenobarbital, phenytoin, or theophylline.

    • May I receive this medication if I am pregnant or breastfeeding?

      Caffeine citrate is used only for premature infants.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of caffeine citrate, give it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and return to the regular dosing schedule. Do not give two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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