• Required field
  • Generic Name: (pyrimethamine)
    Other Brands: N/A
  • Last Revised: 12/2015
    • What is this medication and its most common uses?

      Daraprim is a medicine used in combination with other medicines to treat certain infections, such as toxoplasmosis and malaria. It is also used to prevent malaria.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Daraprim is thought to stop the growth of certain organisms causing your infection.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: By stopping the growth of certain organisms causing the infection, Daraprim may help to relieve your symptoms and eliminate the infection.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Daraprim exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order certain tests to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: allergic reactions, loss of appetite, vomiting, low blood cell counts.

      Less common side effects may include:

      Daraprim may increase the risk of developing cancer.

    • Who should not take this medication?

      Do not take Daraprim if you are allergic to it or any of its ingredients.

      Do not take Daraprim if you have a history of a certain type of anemia (low red blood cell counts) due to folate deficiency.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Daraprim. Also, talk to your healthcare provider about your complete medical history, especially if you have seizures, kidney or liver problems, malabsorption syndrome, if you drink alcohol, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.


      Adults: The usual starting dose is 50 to 75 milligrams (mg) a day.

      Children: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her weight.

      Your healthcare provider may adjust the dose as needed, until the desired effect is achieved.

      Malaria Treatment

      Adults: The usual dose is 25 or 50 mg for 2 days.

      Children 4-10 years: The usual dose is 25 mg for 2 days.

      Malaria Prevention

      Adults and children >10 years: The usual dose is 25 mg (1 tablet) once a week.

      Children 4-10 years: The usual dose is 12.5 mg (1/2 tablet) once a week.

      Children <4 years: The usual dose is 6.25 mg (1/4 tablet) once a week.

    • How should I take this medication?

      Take Daraprim exactly as prescribed by your healthcare provider. Do not change your dose or stop taking it without first talking to your healthcare provider.

      If you experience a rash, sore throat, paleness, or a swollen tongue, stop taking Daraprim and notify your healthcare provider immediately.

      If you experience loss of appetite or vomiting, you may take Daraprim with meals.

    • What should I avoid while taking this medication?

      Do not become pregnant or plan to become pregnant without first checking with your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Daraprim is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Daraprim with the following: certain sulfonamides (such as sulfamethoxazole), lorazepam, methotrexate, phenytoin, proguanil, or zidovudine.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Daraprim during pregnancy are unknown. Daraprim can be found in your breast milk if you take it while breastfeeding. Do not breastfeed while you are taking Daraprim. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Daraprim, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature, in a dry place. Protect from light.

    • Who should I contact in case of emergency or overdose?
      back to top

      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
  • Terms of Service

    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.