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  • Generic Name: (estradiol valerate)
    Other Brands: N/A
  • Last Revised: 11/2014
    • What is this medication and its most common uses?

      Delestrogen is a medicine that contains an estrogen hormone. Delestrogen is used to reduce hot flashes due to menopause and treat menopausal changes in and around the vagina. Delestrogen is also used to treat certain conditions in women if their ovaries do not make enough estrogen naturally, and to ease symptoms of prostate cancer in men that have spread throughout the body. Delestrogen is administered as intramuscular (into your muscle) injections.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Menopausal women have lower levels of the hormone estrogen in their bodies, resulting in symptoms such as hot flashes and vaginal changes. Delestrogen provides estrogen to help relieve those symptoms.

      What are the beneficial effects of this medication and when should I begin to have results?


      Hot Flashes: Delestrogen may reduce the number of hot flashes a woman experiences.

      Vaginal Symptoms: Delestrogen may improve vaginal symptoms due to menopause, such as severe dryness, itching, and burning.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions.

      How do I know it is working?

      You may notice an improvement in your symptoms after you start receiving Delestrogen. Your healthcare provider may also ask you questions from time to time to assess how well this medication is working.


    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Using estrogen-only medicines such as Delestrogen may increase your chance of developing endometrial cancer (cancer of the uterus). Tell your healthcare provider right away if you experience any unusual vaginal bleeding while you are using Delestrogen. Vaginal bleeding after menopause may be a warning sign of endometrial cancer.

      Do not use Delestrogen in combination with progestins to prevent heart disease, heart attacks, strokes, or dementia. Using Delestrogen in combination with progestins may increase your chance of a heart attack, stroke, blood clots, or dementia. Using Delestrogen in combination with progestins may also increase your chance of developing breast cancer.

      More common side effects may include: headache, breast pain, irregular vaginal bleeding or spotting, abdominal (stomach area) cramps, nausea, vomiting, hair loss.

      Less common side effects may include:

      Vision problems, with symptoms such as double vision, bulging eyes, or sudden new severe headaches.

      Delestrogen may also cause gallbladder problems, increased blood calcium levels, increased blood pressure, or increased triglyceride (type of fat in the blood) levels.


    • Who should not take this medication?

      Your healthcare provider will not administer Delestrogen to you if you are allergic to it or any of its ingredients.

      Your healthcare provider will not administer Delestrogen to you if you have unusual vaginal bleeding.

      Your healthcare provider will not administer Delestrogen to you if you have or have had certain cancers (including breast cancer), blood clots, or liver problems.

      Your healthcare provider will not administer Delestrogen to you if you had a stroke or a heart attack.

      Your healthcare provider will not administer Delestrogen to you if you are pregnant or think you may be pregnant.


    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Delestrogen. Also, talk to your healthcare provider about your complete medical history, especially if you have asthma; seizures; diabetes; migraines; endometriosis (a common gynecological disorder that may result in sores and pain); lupus (a disease that affects the immune system); heart, liver, thyroid, or kidney problems; high or low blood calcium levels; porphyria (a blood disorder); if you are scheduled for surgery; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you based on your condition.

    • How should I take this medication?

      Your healthcare provider will administer Delestrogen to you.

      Estrogens should be used at the lowest dose possible for your treatment only as long as needed. You and your healthcare provider should talk regularly (for example, every 3 to 6 months) about the dose you are using and whether you still need treatment with Delestrogen.


    • What should I avoid while taking this medication?

      Do not become pregnant while you are receiving Delestrogen.

    • What are the possible food and drug interactions associated with this medication?

      If Delestrogen is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Delestrogen with the following: carbamazepine, clarithromycin, erythromycin, grapefruit juice, itraconazole, ketoconazole, phenobarbital, rifampin, ritonavir, or St. John's wort.

    • May I receive this medication if I am pregnant or breastfeeding?

      Do not become pregnant while you are receiving Delestrogen. Delestrogen can be found in your breast milk if you receive it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Delestrogen should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Your healthcare provider will store this medication for you.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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