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  • Generic Name: (mesalamine)
    Other Brands: N/A
  • Last Revised: 07/2016
    • What is this medication and its most common uses?

      Delzicol is a medicine used to treat and maintain control of symptoms of ulcerative colitis (an inflammatory disease of the large intestine).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Delzicol is thought to work by blocking a substance in your body that is involved in causing inflammation and pain in the colon.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Studies have shown that Delzicol is effective in reducing rectal bleeding and stool frequency.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Delzicol exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may notice an improvement in your ulcerative colitis symptoms after you start taking Delzicol. This is a good indicator that the medicine is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: abdominal (stomach area) pain, burping, back pain, rash, upset stomach, runny nose, flu-like symptoms, weakness, gas, vomiting, fever, joint pain, constipation, stomach or intestinal bleeding.

      Less common side effects may include:

      Allergic reactions with symptoms such as inflammation of the heart muscle or the lining of the heart.

      The medicine in Delzicol has been associated with a condition that may be hard to tell apart from an ulcerative colitis flare-up, with symptoms including cramping, abdominal pain, bloody diarrhea, fever, headache, or rash.

      Delzicol may also cause kidney or liver problems.

    • Who should not take this medication?

      Do not take Delzicol if you are allergic to it, any of its ingredients, or to aspirin or medicines that contain aspirin.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Delzicol. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or liver problems, are allergic to sulfasalazine, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.


      Adults: The recommended dose is 2 capsules three times a day for 6 weeks.

      Children ≥5 years: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her weight.


      Adults: The recommended dose is 1.6 grams a day, in divided doses.

    • How should I take this medication?

      Take Delzicol exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Delzicol without first talking to your healthcare provider.

      Take Delzicol with or without food.

      Swallow Delzicol whole. Do not open, crush, break, or chew the capsules.

      If you are unable to swallow the capsule whole, open the capsules required and swallow the tablets whole. There are 4 tablets per capsule. Do not cut, break, crush, or chew the tablets.

      When you take Delzicol, you may see something in your stool that looks like a capsule after you have a bowel movement. This is normal, and is the empty shell from the capsule after the medicine has been absorbed in your body. Contact your healthcare provider if this occurs repeatedly.

    • What should I avoid while taking this medication?

      Do not stop taking Delzicol if you see a capsule shell in your stool without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Delzicol is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Delzicol with the following: 6-mercaptopurine, azathioprine, or nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen and naproxen).

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Delzicol during pregnancy are unknown. Delzicol can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Delzicol, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from moisture.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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