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  • Generic Name: (demeclocycline hydrochloride)
    Other Brands: N/A
  • Last Revised: 12/2014
    • What is this medication and its most common uses?

      Demeclocycline is an antibiotic used to treat certain bacterial infections, including infections of the skin, respiratory tract, and urinary tract, and certain sexually transmitted diseases (such as Chlamydia). Demeclocycline may also be used to treat other bacterial infections, as determined by your healthcare provider.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Demeclocycline works by stopping the growth of bacteria, thereby treating your infection.

      Demeclocycline does not treat viral infections, such as the common cold.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Demeclocycline may help to treat your infection, thereby improving your symptoms.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take demeclocycline exactly as your healthcare provider has prescribed for the full course of treatment, even if your symptoms improve earlier.

      How do I know it is working?

      You may start to notice an improvement in your symptoms. This is a good indicator that your medication is working. Your healthcare provider may ask you questions and order tests to assess how well your infection is being treated.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: loss of appetite, nausea, dizziness, headache.

      Less common side effects may include:

      Permanent tooth discoloration (yellow-gray-brown) in babies or children, especially if taken during tooth development (during the last half of pregnancy and from birth to 8 years of age).

      Watery and bloody stools (with or without stomach cramps and fever), even as late as two or more months after taking the last dose of demeclocycline.

      High pressure in the fluid around your brain, with symptoms such as blurred vision, vision loss, or unusual headaches.

      Central nervous system (the brain and spinal cord) effects, with symptoms such as lightheadedness, dizziness, or a spinning feeling.

      Onset of nephrogenic diabetes insipidus syndrome (a disorder in which a defect in the kidneys causes a person to pass a large amount of urine and lose too much water).

      Demeclocycline can harm your unborn baby. Talk to your healthcare provider about other treatment options if you plan to become pregnant. Tell your healthcare provider right away if you become pregnant while taking demeclocycline.

    • Who should not take this medication?

      Do not take demeclocycline if you are allergic to it, any of its ingredients, or to other similar medicines (such as tetracycline).

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with demeclocycline. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or liver problems, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The usual dose is 150 milligrams (mg) four times a day or 300 mg two times a day.

      Children >8 years: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her weight.

      If you have kidney or liver impairment, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take demeclocycline exactly as prescribed by your healthcare provider. Do not change your dose or stop taking demeclocycline without first talking to your healthcare provider.

      Take demeclocycline with a full glass of liquid to lower your chance of getting irritation or ulcers in your esophagus (the tube that connects your mouth and stomach).

      Take demeclocycline at least 1 hour before or 2 hours after meals.

    • What should I avoid while taking this medication?

      Do not drive, operate machinery, or engage in other activities that require mental alertness or coordination until you know how demeclocycline affects you.

      Do not expose yourself to sunlamps or tanning beds, and try to limit your time in the sun, as demeclocycline can increase your sensitivity to light. If you need to be outdoors, use sunscreen and wear a hat and loose-fitting clothes that protect your skin from the sun.

      Do not skip doses. Skipping doses or not completing the full course of demeclocycline can decrease its effectiveness and can lead to the growth of bacteria that are resistant to the effects of demeclocycline.

    • What are the possible food and drug interactions associated with this medication?

      If demeclocycline is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining demeclocycline with the following: antacids that contain aluminum, calcium, or magnesium; birth control pills; blood thinners (such as warfarin); iron-containing products; methoxyflurane; or penicillin.

    • May I receive this medication if I am pregnant or breastfeeding?

      Demeclocycline may harm your unborn baby if taken during pregnancy. Demeclocycline can be found in your breast milk if you take it while breastfeeding. Do not breastfeed while you are taking demeclocycline. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of demeclocycline, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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