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Fabrazyme is a medicine used to treat patients with Fabry disease (an inherited disorder caused by a deficiency of an enzyme called alpha-galactosidase beta [alpha-GAL]). Fabrazyme is administered intravenously (through a vein in your arm).
How does this medication work?
Fabrazyme works by replacing the deficient enzyme in people with Fabry disease.
What are the beneficial effects of this medication and when should I begin to have results?
What: By replacing the deficient enzyme, Fabrazyme may help to relieve your symptoms.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider’s directions.
How do I know it is working?
Your healthcare provider may order tests regularly to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: infusion-related reactions such as chills, fever, feeling hot or cold, trouble breathing, nausea, flushing, headache, vomiting, numbness, tiredness, redness, pain in your legs, changes in blood pressure, chest pain, throat tightness, stomach area pain, dizziness, fast or slow heart rate, nasal congestion, diarrhea, swelling of your legs and feet, muscle pain, back pain, pale skin, itching, swelling of your face, rash, or sleepiness.
Less common side effects may include:
Serious or life-threatening allergic reactions with symptoms such as swelling of the face, mouth or throat, airway narrowing, low blood pressure, a rash, trouble swallowing, trouble breathing, warm, hot or burning feeling to your face, chest discomfort, itching, and blockage of the nasal passages.
Your healthcare provider will not administer Fabrazyme to you if you are allergic to it or any of its ingredients.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Fabrazyme. Also, talk to your healthcare provider about your complete medical history, especially if you have heart problems, or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults and children ≥8 years: Your healthcare provider will prescribe the appropriate dose for you or your child, based on the body weight.
Your healthcare provider will administer Fabrazyme to you.
Do not miss any scheduled follow-up appointments with your healthcare provider.
No significant interactions have been reported with Fabrazyme at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.
The effects of Fabrazyme during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you are a woman of childbearing age, talk to your healthcare provider about registering Fabry Registry. The purpose of this registry is to collect information about the safety of Fabrazyme during pregnancy.
Fabrazyme should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.
Your healthcare provider will store this medication for you.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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