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  • Generic Name: (estradiol acetate)
    Other Brands: N/A
  • Last Revised: 08/2016
    • What is this medication and its most common uses?

      Femring is a vaginal ring that contains an estrogen hormone. Femring is used to reduce hot flashes associated with menopause and to treat menopausal changes in and around the vagina.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Menopausal women have lower levels of the hormone estrogen in their bodies, resulting in symptoms such as hot flashes and vaginal changes. Femring provides estrogen to help relieve those symptoms.

      What are the beneficial effects of this medication and when should I begin to have results?


      Hot Flashes: Femring has been shown to reduce the number and the severity of hot flashes a woman experiences. Hot flashes may become less frequent and intense after you start using Femring.

      Vaginal Symptoms: Femring may improve vaginal symptoms (such as severe dryness, itching, and burning) due to menopause.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions. It is important that you use Femring exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may notice an improvement in your symptoms after you insert Femring. Your healthcare provider may also ask you questions from time to time to assess how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Using estrogen-only medicines such as Femring may increase your chance of developing endometrial cancer (cancer of the uterus). Tell your healthcare provider right away if you experience any unusual vaginal bleeding while you are using Femring. Vaginal bleeding after menopause may be a warning sign of endometrial cancer.

      Do not use Femring alone to prevent heart disease, heart attacks, strokes, or dementia (a decline in brain function). Using Femring alone may increase your chance of getting strokes, blood clots, or dementia.

      Do not use Femring in combination with progestins to prevent heart disease, heart attacks, strokes, or dementia. Using Femring in combination with progestin may increase your chance of a heart attack, stroke, blood clots, or dementia. Using Femring in combination with progestin may also increase your chance of developing breast cancer. You and your healthcare provider should talk regularly about whether you still need treatment with Femring.

      More common side effects may include: vaginal bleeding, breast tenderness.

      Less common side effects may include:

      Increased risk of developing ovarian cancer or gallbladder disease requiring surgery.

      Vision problems, with symptoms such as double vision, bulging eyes, or sudden new severe headaches.

      Femring may also cause increased blood calcium levels, increased blood pressure, increased triglyceride (type of fat in the blood) levels, thyroid problems, or swelling.

    • Who should not take this medication?

      Do not use Femring if you are allergic to it or any of its ingredients.

      Do not use Femring if you have unusual vaginal bleeding.

      Do not use Femring if you have or have had certain cancers (including breast cancer), blood clots, or liver problems.

      Do not use Femring if you have been diagnosed with a bleeding disorder.

      Do not use Femring if you had a stroke or a heart attack.

      Do not use Femring if you are pregnant or think you may be pregnant.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Femring. Also, talk to your healthcare provider about your complete medical history, especially if you are pregnant, plan to become pregnant, or are breastfeeding, or if you have any of the following: any unusual vaginal bleeding; any problems with your vagina or cervix; asthma; seizures; diabetes; migraines; endometriosis (a common gynecological disorder that may result in sores and pain); lupus (a disease that affects the immune system); heart, liver, thyroid, or kidney problems; high blood calcium levels; porphyria (a blood disorder); angioedema (a condition involving swelling of the face, extremities, eyes, lips, and tongue); any scheduled surgery.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Women: The recommended starting dose is 0.05 milligrams/day. Your healthcare provider may adjust your dose as needed, until the desired effects are achieved.

    • How should I take this medication?

      Use Femring exactly as prescribed by your healthcare provider.

      Insert immediately upon removal from the protective pouch.

      Femring should stay in your vagina for 90 days. After 90 days, Femring should be removed. If you and your healthcare provider decide you should continue using Femring, a new Femring can be inserted.

      You and your healthcare provider should talk regularly (for example, every 3 to 6 months) about the dose of medicine you are using and whether you still need treatment with Femring.

      Contact with blood may cause discoloration of Femring during use. This does not affect the way in which Femring releases medicine to control your menopausal symptoms. Call your healthcare provider right away if you have unusual vaginal bleeding.

      Be sure to review the instructions that came with your prescription before you start using Femring.

    • What should I avoid while taking this medication?

      Do not become pregnant while you are using Femring.

    • What are the possible food and drug interactions associated with this medication?

      If Femring is used with certain other drugs, the effects of either could be increased, decreased, or altered. Femring may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Do not become pregnant or breastfeed while you are using Femring. The ingredients in Femring can be found in your breast milk if you use it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Femring should be used under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Store at room temperature. Do not store unpouched.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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