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  • Generic Name: (obinutuzumab)
    Other Brands: N/A
  • Last Revised: 03/2016
    • What is this medication and its most common uses?

      Gazyva is a medicine used in combination with another medicine called chlorambucil for the treatment of a type of cancer called chronic lymphocytic leukemia. Gazyva is also used to treat a type of cancer called follicular lymphoma. Gazyva is administered intravenously (injected directly into your vein).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Gazyva works by destroying the cancer cells in your body.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: In a clinical study, people receiving Gazyva in combination with chlorambucil experienced an average of 27 months without their cancer getting worse.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working. 

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      If you have a history of hepatitis B infection, Gazyva could cause it to return. Your healthcare provider may screen for a hepatitis B infection before starting therapy.

      Gazyva may increase your risk of developing progressive multifocal leukoencephalopathy (a rare but serious brain infection caused by a certain virus) that may be life-threatening. Symptoms include new or changes in neurological symptoms such as confusion, dizziness or loss of balance, difficulty talking or walking, or vision changes.

      More common side effects for chronic lymphocytic leukemia may include: infusion reactions; low white blood cell, red blood cell, and platelet (a type of blood cells that form clots to help stop bleeding) counts; fever; cough; nausea; diarrhea.

      More common side effects for lymphoma may include: infusion reactions; low white blood cell, red blood cell, and platelet counts; nausea; tiredness; cough; diarrhea; constipation; fever; vomiting; upper respiratory infection; decreased appetite; joint pain; sinus pain or inflammation; weakness; urinary tract infection.

      Less common side effects of Gazyva may include:

      Tumor lysis syndrome (a condition caused by a sudden breakdown of cancer cells) with symptoms such as nausea, vomiting, diarrhea, or tiredness.

      Gazyva may also cause increased risk of developing infections.

    • Who should not take this medication?

      Your healthcare provider will not administer Gazyva to you if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Gazyva. Also, talk to your healthcare provider about your complete medical history, especially if you have a history of infections (including hepatitis B), recently received or are scheduled to receive a vaccine, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you.

    • How should I take this medication?

      Your healthcare provider will administer Gazyva to you.

      You will receive Gazyva on certain days of each cycle. On the days you receive Gazyva, be sure to take the medicines prescribed by your healthcare provider to help reduce the risk of side effects during your infusion.

      If you take medicines to control your blood pressure, your healthcare provider may ask you to not take them on the day of your Gazyva infusion.

    • What should I avoid while taking this medication?

      Do not receive live vaccines while you are undergoing treatment with Gazyva. Talk to your healthcare provider about what vaccines to avoid.

      Do not miss any scheduled follow-up appointments with your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Gazyva at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      Gazyva may harm your unborn baby if you receive it during pregnancy. The effects of Gazyva during breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Gazyva should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider for advice.

    • How should I store this medication?

      Your healthcare provider will store this medication for you.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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