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  • Generic Name: (lactulose)
    Other Brands: Enulose
  • Last Revised: 04/2014
    • What is this medication and its most common uses?

      Generlac is a medicine used to prevent and treat worsening of brain function that occurs when the liver is no longer able to remove toxins (such as ammonia) from the blood. Generlac is available as an oral solution.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Generlac works by drawing ammonia from the blood into the colon where it is removed from the body.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Generlac may reduce blood ammonia levels by 25-50%, thereby improving a person's mental state.

      When: Generlac may start working after 24 to 48 hours.

      How do I know it is working?

      You may notice an improvement in your mental state after you start taking Generlac. This is a good indicator that the medicine is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: bloating, gas, bleching, cramps.

      Less common side effects may include: nausea, vomiting.

    • Who should not take this medication?

      Do not take Generlac if you are allergic to it or any of its ingredients.

      Do not take Generlac if you require a low galactose diet.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medication you are taking before beginning treatment with Generlac. Also talk to your healthcare provider about your complete medical history, especially if you are a diabetic or are scheduled to undergo a proctoscopy or colonoscopy.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The usual dose is 2 to 3 tablespoonfuls (30 to 45 milliliters [mL]) three or four times a day. Your healthcare provider may adjust your dose as needed.

      Adolescents and older children: The recommended dose 40 to 90 mL a day.

      Infants: The recommended starting dose 2.5 to 10 mL a day, given in divided doses.

    • How should I take this medication?

      Take Generlac exactly as prescribed by your healthcare provider. Do not change the dose without first talking to your healthcare provider.

      Generlac may darken slightly. This is normal and does not affect the action of the medicine.

      Contact your child's healthcare provider if your child experiences diarrhea after he/she takes the first dose of Generlac.


    • What should I avoid while taking this medication?

      Do not take Generlac if it becomes extremely dark or cloudy after being exposed to high temperatures or direct light for an extended period of time.

    • What are the possible food and drug interactions associated with this medication?

      If Generlac is taken with certain other drugs, the effects of either could be increased, decreased or altered. It is especially important to check with your healthcare provider before combining Generlac with the following: antacids, antibiotics (such as neomycin), or other laxatives.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Generlac during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Generlac, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.