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  • Generic Name: (cyclosporine)
    Other Brands: N/A
  • Last Revised: 05/2015
    • What is this medication and its most common uses?

      Gengraf oral solution is a medicine that is used in combination with other medicines to help prevent organ rejection in people who have had a kidney, liver, or heart transplant. Gengraf oral solution is also used to treat rheumatoid arthritis (a type of arthritis that involves inflammation of the joints) and psoriasis (immune disorder that affects the skin).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Your immune system is your body's defense against things that can cause infection and disease. Unfortunately, it cannot tell the difference between a harmful virus and bacteria and your tissues or new organ, so its natural response is to reject and attack them. Gengraf oral solution works by stopping your immune system from rejecting and attacking your new organ or healthy tissues.

      What are the beneficial effects of this medication and when should I begin to have results?


      Kidney, Liver, or Heart Transplant: Gengraf oral solution may extend survival in people receiving a transplant.

      Rheumatoid Arthritis: Gengraf oral solution has been shown to improve symptoms such as tender and swollen joints.

      Psoriasis: Gengraf oral solution may improve symptoms of psoriasis.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. Though you may not feel a change in the way you feel, it is very important to keep taking your medicine as prescribed to prevent your body from rejecting your new organ or tissues.

      How do I know it is working?

      Your healthcare provider may order tests regularly and may ask you questions from time to time to assess how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Gengraf oral solution can increase your risk of developing lymphoma (a type of cancer involving cells of the immune system, called lymphocytes) and other types of cancers (including skin cancer).

      Gengraf oral solution can increase your risk of developing infections. Tell your healthcare provider immediately if you have symptoms of an infection such as a fever; sweats or chills; cough or flu-like symptoms; muscle aches; or warm, red, or painful areas on your skin.

      Gengraf oral solution may also cause high blood pressure and kidney problems. This risk is increased if you take Gengraf oral solution at higher dosages and with prolonged use. Your healthcare provider may monitor your kidneys during your treatment with Gengraf oral solution.

      Do not use other similar medicines in place of Gengraf oral solution (such as Sandimmune) without first talking to your healthcare provider.

      If you have psoriasis and your previous treatments have included light therapy (such as PUVA OR UVB), methotrexate, or other medicines that suppress your immune system, Gengraf oral solution may increase your risk of developing skin cancer.


      Kidney, Liver, or Heart transplant
      More common side effects may include:
      kidney problems, shaking, excessive growth of facial or body hair in women, high blood pressure, enlargement of the gum.

      Rheumatoid Arthritis
      More common side effects may include:
      kidney problems, high blood pressure, headache, stomach discomfort, abnormal or excessive growth of facial or body hair.

      More common side effects may include:
      kidney problems, headache, high blood pressure, high blood triglyceride (type of fat in the blood) levels, abnormal or excessive growth of facial or body hair, numbness, flu-like symptoms, nausea, vomiting, diarrhea, stomach discomfort, tiredness, muscle or joint pain.

      Less common side effects of Gengraf oral solution may include:

      Low blood count, with symptoms such as red or purple spots on your skin, bruising, bleeding from your mouth, teeth, or nose.

      Nervous system problems, with symptoms such as confusion, muscle tremors, numbness and tingling, headache, seizures, or visions changes.

      Liver problems with symptoms such as nausea, tiredness, weakness, itching, yellowing of your skin or the whites of your eyes, right upper stomach pain, and flu-like symptoms.

      Gengraf oral solution can also cause high blood potassium levels.

    • Who should not take this medication?

      Do not take Gengraf oral solution if you are allergic to it or any of its ingredients.

      Do not take Gengraf oral solution for rheumatoid arthritis or psoriasis if you have kidney problems, uncontrolled high blood pressure, or any type of cancer.

      Do not take Gengraf oral solution for psoriasis if you are currently being treated with light therapy (such as PUVA or UVB), methotrexate, and other medicines that suppress your immune system, coal tar, or radiation therapy.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Gengraf oral solution. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or liver problems; uncontrolled high blood pressure; any type of cancer; plan to receive any live vaccines; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you based on your condition and body weight.

      If you have kidney or liver impairment, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Gengraf oral solution exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Gengraf oral solution without first talking to your healthcare provider.

      Take Gengraf oral solution with or without food. Take it the same way and at the same time every day.

      Using the dosing syringe provided, mix your dose of Gengraf oral solution with a glass of room temperature orange or apple juice. Stir well and drink immediately.

      Do not rinse the dosing syringe with water or other cleaning agents. If it requires cleaning, make sure the syringe is completely dry before reusing. Ask your healthcare provider or pharmacist if you are not sure what dose you should take or if you are not sure how to use the dosing syringe.

      Taking Gengraf oral solution at the same time each day helps to keep enough medicine in your body to give your transplanted organ the around-the-clock medicine it needs.

    • What should I avoid while taking this medication?

      Do not eat grapefruit or drink grapefruit juice while you are taking Gengraf oral solution.

      Do not receive any live vaccines (such as flu vaccine through your nose, or measles, mumps, rubella, polio, tuberculosis, yellow fever, chicken pox, or typhoid vaccines) while you are taking Gengraf oral solution.

      Do not expose yourself to excessive sunlight and ultraviolet light, such as tanning machines. Wear protective clothing and use sunscreen.

      Do not miss any scheduled follow-up appointments with your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Gengraf oral solution is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Gengraf oral solution may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Gengraf oral solution during pregnancy are unknown. The ingredients in Gengraf oral solution can be found in your breast milk. Do not breastfeed while you are taking Gengraf oral solution. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Gengraf oral solution should be taken under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Store at room temperature. Use within 2 months of opening.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.