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Harvoni is a medicine used with or without ribavirin to treat chronic (long-term) hepatitis C virus infection. Harvoni contains two medications: ledipasvir and sofosbuvir.
How does this medication work?
Harvoni works by lowering the ability of the virus to multiply in your body, thereby helping to stop the virus from spreading.
What are the beneficial effects of this medication and when should I begin to have results?
What: Studies show that people treated with Harvoni achieved sustained virologic response, which means that the chronic hepatitis C virus can no longer be found in the blood as early as 8 weeks at the end of treatment.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Harvoni exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may order blood tests regularly to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: tiredness, headache, lack of strength.
Less common side effects may include:
Slow heart rate when taken with another medicine called amiodarone, with symptoms such as near-fainting or fainting, dizziness, lightheadedness, weakness, tiredness, shortness of breath, chest pain, confusion, or memory problems.
Do not take Harvoni if you are allergic to it or any of its ingredients.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Harvoni. Also, talk to your healthcare provider about your complete medical history, especially if you have liver problems other than hepatitis C infection, had a liver transplant, HIV infection, severe kidney problems or are on dialysis, or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended dose is one tablet once a day.
Take Harvoni exactly as prescribed by your healthcare provider.
Take Harvoni with or without food at the same time each day.
Do not change your dose or stop taking Harvoni without first talking to your healthcare provider.
Do not miss or skip doses of Harvoni during treatment.
If Harvoni is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Harvoni may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
The effects of Harvoni during pregnancy and breastfeeding are unknown. Do not become pregnant if you are taking Harvoni with another medicine called ribavirin. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Harvoni, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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