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  • Generic Name: (immune globulin subcutaneous (human))
    Other Brands: N/A
  • Last Revised: 12/2014
    • What is this medication and its most common uses?

      Hizentra is a medicine used to treat a condition called primary immune deficiency. Hizentra is given subcutaneously (injected directly under your skin).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      People with primary immune deficiency lack the healthy antibodies needed to fight off infections. Hizentra provides those healthy antibodies.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Hizentra helps lower the number of infections you will get.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider’s directions. It is important that you take Hizentra exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may notice a decrease in the number and severity of your infections after you start using Hizentra.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      A blood clot may develop in your body while you are using Hizentra. Contact your healthcare provider immediately if you experience signs or symptoms of a blood clot, such as pain and/or swelling of an arm or leg with warmth over the affected area, discoloration of an arm or leg, unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained fast heartbeat, or numbness or weakness on one side of the body.

      More common side effects may include: redness, swelling, itching, and/or bruising at the injection site; headache/migraine; diarrhea; tiredness; pain (including pain in the back, joints, arms, legs); nausea and/or vomiting; cough; rash; itching; abdominal (stomach area) pain.

      Less common side effects may include:

      Severe allergic reaction, with symptoms such as hives, trouble breathing, wheezing, dizziness, or fainting.

      A type of brain swelling called aseptic meningitis, with symptoms such as severe headache with nausea, vomiting, stiff neck, drowsiness, fever, painful eye movements, and sensitivity to light.

      Kidney problems, with symptoms such as reduced urination, sudden weight gain, or swelling in your legs.

      A type of blood problem called hemolytic anemia, with symptoms such as brown or red urine, increased heart rate, or yellowing of your skin or the whites of your eyes.

      A lung problem called transfusion-related acute lung injury, with symptoms such as chest pain, trouble breathing, fever, or blue lips, arms, or legs.

      Increased risk of infection with fever >100°F.

    • Who should not take this medication?

      Do not use Hizentra if you are allergic to it or any of its ingredients (including polysorbate 80).

      Do not use Hizentra if you have a condition called hyperprolinemia (too much proline in your blood).

      Do not use Hizentra if you have been told that you also have a deficiency of the immunoglobulin called IgA.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Hizentra. Also, talk to your healthcare provider about your complete medical history, especially if you have a history of heart or blood vessel problems, blood clots, have thick blood, or if you have been immobile for some time.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you.

    • How should I take this medication?

      Use Hizentra exactly as prescribed by your healthcare provider. Do not use Hizentra by yourself until you have been taught how by your doctor or healthcare professional.

      You will receive Hizentra through an infusion, only under your skin. Make sure that the infusion is not into a blood vessel. You will place up to 4 needles into different areas of your body each time you use Hizentra. The needles are attached to a pump with an infusion tube.

      You will need to have infusions once a week or every two weeks, as determined by your healthcare provider. It usually takes about 1 to 2 hours to complete one infusion; however, the infusion may take longer depending on what your healthcare provider has prescribed for you.

      Please review the instructions that came with your prescription on how to use Hizentra.

    • What should I avoid while taking this medication?

      Do not receive live vaccines (such as measles, mumps, rubella, and varicella) while you are undergoing treatment with Hizentra. Talk to your healthcare provider about what vaccines to avoid.

    • What are the possible food and drug interactions associated with this medication?

      If Hizentra is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Hizentra with a live vaccine.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Hizentra during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Hizentra should be used under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider for advice.

    • How should I store this medication?

      Store at room temperature for up to 30 months. Do not shake or freeze.

      Keep Hizentra in its original container to protect it from light.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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