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  • Generic Name: (canakinumab)
    Other Brands: N/A
  • Last Revised: 10/2016
    • What is this medication and its most common uses?

      Ilaris is a medicine used to treat adults and children who have auto-inflammatory diseases called cryopyrin-associated periodic syndromes (CAPS), tumor necrosis factor receptor associated periodic syndrome (TRAPS), hyperimmunoglobulin D syndrome (HIDS)/(also known as mevalonate kinase deficiency [MKD]), and familial Mediterranean fever (FMF). Ilaris is also used to treat children with systemic juvenile idiopathic arthritis (SJIA). Ilaris is administered subcutaneously (injected just below your skin).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Ilaris works by blocking the action of a protein in the body that causes inflammation, thereby helping to improve your condition.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Ilaris may help to improve symptoms associated with CAPS, TRAPS, HIDS/MKD, FMF, or SJIA.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions.

      How do I know it is working?

      Your healthcare provider may ask you questions from time to time to check how well your symptoms are controlled with treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects when used for CAPS may include: common cold, diarrhea, flu, runny nose, nausea, headache, cough, gastroenteritis (nausea, vomiting, and diarrhea), sore throat, weight gain, body aches, and vertigo (feeling like you are spinning).

      More common side effects when used for TRAPS, HIDS/MKD, and FMF may include: injection-site reactions (such as redness, swelling, warmth, or itching), common cold.

      More common side effects when used for SJIA may include: common cold, upper respiratory infection, abdominal (stomach area) pain, injection-site reactions.

      Less common side effects of Ilaris may include:

      Increased risk of serious infections, with symptoms such as fever, sweats or chills, cough, flu-like symptoms, weight loss, shortness of breath, blood in your phlegm, sores on your body, warm or painful areas on your body, diarrhea or stomach pain, or feeling very tired. Ilaris can lower the ability of your immune system to fight infections. Your healthcare provider should test you for tuberculosis (TB) before you receive Ilaris, monitor you closely for symptoms of TB during treatment, and check you for symptoms of any type of infection before, during, and after your treatment with Ilaris.

      Allergic reactions, with symptoms such as rash, itching and hives, difficulty breathing or swallowing, dizziness, or feeling faint.

      Ilaris may also increase your risk of getting cancer.

    • Who should not take this medication?

      Your healthcare provider will not administer Ilaris to you if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Ilaris. Also, talk to your healthcare provider about your complete medical history, especially if you have symptoms of an infection or are being treated for an active infection; have or have had HIV, hepatitis B, or hepatitis C; have a history of infections that keep coming back or low white blood cells; are scheduled to receive any vaccines; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults and children: Your healthcare provider will prescribe the appropriate dose for you, based on your weight and the condition being treated.

    • How should I take this medication?

      Your healthcare provider will administer Ilaris to you.

      Ilaris is given every 8 weeks for CAPS and every 4 weeks for TRAPS, HIDS/MKD, FMF, and SJIA.

    • What should I avoid while taking this medication?

      Do not miss any scheduled follow-up appointments with your healthcare provider.

      Do not receive any live vaccines during treatment with Ilaris. Talk to your healthcare provider about what vaccines to avoid.

    • What are the possible food and drug interactions associated with this medication?

      If Ilaris is used with certain other drugs, the effects of either could be increased, decreased, or altered. Ilaris may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Ilaris during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Ilaris should be used under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider for advice.

    • How should I store this medication?

      Your healthcare provider will store this medication for you.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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