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  • Generic Name: (ibrutinib)
    Other Brands: N/A
  • Last Revised: 07/2016
    • What is this medication and its most common uses?

      Imbruvica is a medicine used to treat people with mantle cell lymphoma who have already been treated with at least one prior treatment. Imbruvica is also used to treat people with chronic lymphocytic leukemia/small lymphocytic lymphoma and Waldenstrom's macroglobulinemia.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Imbruvica works by helping to stop the multiplication and spread of cancer cells.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: By stopping the spread of cancer cells, Imbruvica may help to improve your condition.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions. It is important that you take Imbruvica exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: low blood platelet (type of blood cells that form clots to help stop bleeding), white blood cell, and red blood cell counts; diarrhea; tiredness; muscle and bone pain; bleeding; nausea; bruising; rash; fever.

      Less common side effects may include:

      Bleeding problems, with symptoms such as blood in your stools or black stools (looks like tar), pink or brown urine, unexpected bleeding or bleeding that is severe or that you cannot control, vomiting blood or vomit looks like coffee grounds, coughing up blood, increased bruising, feel dizzy or weak, confusion, change in your speech, or a headache that lasts a long time.

      Infection, with symptoms such as fever, chills, weakness, confusion, or other signs or symptoms of an infection.

      Heart rhythm problems, with symptoms such as feeling as if your heart is beating fast or irregular, lightheadedness, dizziness, shortness of breath, chest discomfort, or fainting.

      Development of new cancers, including cancers of the skin or other organs.

      Tumor lysis syndrome (fast breakdown of cancer cells) with symptoms such as abnormal heart rhythm and seizures.

      Harm to your unborn baby if taken during pregnancy. Females should not become pregnant while taking Imbruvica and for 1 month after ending treatment.

      Imbruvica may also cause new or worsening high blood pressure.

    • Who should not take this medication?

      Do not take Imbruvica if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Imbruvica. Also, talk to your healthcare provider about your complete medical history, especially if you have liver or bleeding problems; have an infection; have or had a history of heart rhythm problems; if you smoke; have a condition that increases your risk of heart disease (such as high blood pressure, high cholesterol, or diabetes); have undergone recent surgery or plan to have surgery; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Mantle Cell Lymphoma

      Adults: The recommended dose is four 140-milligram (mg) capsules once a day.

      Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Waldenstrom's Macroglobulinemia

      Adults: The recommended dose is three 140-mg capsules once a day.

      If you have liver problems, are taking certain other medicines, or experience certain side effects while you are taking Imbruvica, your healthcare provider may adjust your dose.

    • How should I take this medication?

      Take Imbruvica exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Imbruvica without first talking to your healthcare provider.

      Take Imbruvica at about the same time each day.

      Swallow Imbruvica capsules whole with a glass of water. Do not open, break, or chew the capsules.

      Drink plenty of fluids while you are taking Imbruvica to help reduce your risk of dehydration due to diarrhea.

    • What should I avoid while taking this medication?

      Do not drink grapefruit juice, eat grapefruit, or eat Seville oranges (often used in marmalades) during treatment with Imbruvica. These products may increase the amount of Imbruvica in your blood.

    • What are the possible food and drug interactions associated with this medication?

      If Imbruvica is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Imbruvica may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Imbruvica may harm your unborn baby if taken during pregnancy. If you are able to become pregnant, your healthcare provider may do a pregnancy test before starting treatment. Women should not become pregnant while taking Imbruvica and for 1 month after ending treatment. Males should also avoid getting female partners pregnant during treatment and for 1 month after the last dose of Imbruvica. The effects of Imbruvica during breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Imbruvica, take it as soon as possible on the same day and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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