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  • Generic Name: (sumatriptan succinate)
    Other Brands: N/A
  • Last Revised: 11/2015
    • What is this medication and its most common uses?

      Imitrex injection is a medicine used to treat migraine attacks with or without aura (vision, hearing, or movement disturbances) and cluster headaches. Imitrex injection is injected subcutaneously (just below the skin), and is available as a single-dose vial and a prefilled syringe called Statdose Pen.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      A migraine occurs when swollen blood vessels in the brain press on nearby nerves. Imitrex injection works by narrowing those blood vessels, helping to improve your migraine symptoms.

      This medicine is not used to prevent migraine attacks. Always follow the instructions your healthcare provider gave you for preventing migraines.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: In addition to reducing headache pain, Imitrex injection has been shown to decrease migraine-associated symptoms, such as nausea and sensitivity to light and sound.

      When: Imitrex injection may relieve your migraine pain within 10 minutes.

      How do I know it is working?

      You may feel relief in your migraine or cluster headache after you use Imitrex injection. This is a good indicator that the medicine is working. Recording your headache frequency and medication use may be helpful to you and your healthcare provider in monitoring your progress.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: pain or redness at your injection site; tingling or numbness of your hands or feet; dizziness; warm or hot sensation; burning or pressure sensation; feeling of heaviness; flushing (warm, hot, burning feeling to your face); feeling of tightness.

      Less common side effects may include:

      Heart attack or other heart problems, with symptoms such as discomfort in the center of your chest that lasts for more than a few minutes or that goes away and comes back; severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw; pain or discomfort in your arms, back, neck, jaw, or stomach; shortness of breath with or without chest discomfort; breaking out in a cold sweat; nausea or vomiting; or lightheadedness.

      Bleeding in the brain or stroke, with symptoms such as numbness or weakness in your face, arm, or leg, especially on one side of your body; confusion; problems speaking or understanding; problems seeing in one or both of your eyes; problems walking; dizziness; loss of balance or coordination; or severe headache with no known cause.

      Stomach or intestinal problems, with symptoms such as sudden or severe stomach pain, stomach pain after meals, weight loss, nausea or vomiting, constipation or diarrhea, bloody diarrhea, or fever.

      Problem with blood circulation to your legs or feet, with symptoms such as cramping and pain in your legs or hips; feeling of heaviness or tightness in your leg muscles; burning or aching pain in your feet or toes while resting; cold feeling or color changes in one or both legs or feet; or numbness, tingling, or weakness in your legs.

      Serotonin syndrome (a potentially life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by the nerve cells) with symptoms such as mental status changes (such as agitation or hallucinations), an increase in your heart rate and body temperature, changes in blood pressure, lack of coordination, overactive reflexes, muscle rigidity, nausea, vomiting, or diarrhea.

      Serious allergic reactions with symptoms such as hives or swelling of your tongue, mouth, or throat.
      Imitrex injection may also cause arrhythmias (a life-threatening irregular heartbeat), seizures, or increase your blood pressure.

    • Who should not take this medication?

      Do not use Imitrex injection if you are allergic to it or any of its ingredients.

      Do not use Imitrex injection if you have a history of heart problems, stroke or "mini-stroke," problems with your blood circulation, or narrowing of blood vessels to your legs, arms, stomach, or kidneys. Do not use Imitrex injection if you have high blood pressure that is not controlled with medications.

      Do not use Imitrex injection if you have taken similar medicines (such as almotriptan or eletriptan) or ergot-containing medicines (such as dihydroergotamine or methysergide) within the last 24 hours.

      Do not use Imitrex injection if you take or have taken monoamine oxidase inhibitors (MAOIs) (such as phenelzine or tranylcypromine), a class of medications used to treat depression and other psychiatric conditions, within the last 2 weeks.

      Do not use Imitrex injection if you have certain types of migraines known as hemiplegic or basilar migraines, or severe liver problems.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Imitrex injection. Also, talk to your healthcare provider about your complete medical history, especially if you have heart or liver problems; high blood pressure; high cholesterol; diabetes; seizures; a family history of heart disease or stroke; are not using effective birth control; if you smoke or are overweight; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is a single injection just below the skin, as directed by your healthcare provider.

    • How should I take this medication?

      Use Imitrex injection exactly as prescribed by your healthcare provider. Do not use extra doses without first talking to your healthcare provider.

      If your headache comes back after your first injection, you may use a second injection 1 hour after the first injection, but not sooner. Do not use more than 12 milligrams in 24 hours.

    • What should I avoid while taking this medication?

      Do not drive a car, operate heavy machinery, or engage in other activities that require you to be alert until you know how Imitrex injection affects you.

    • What are the possible food and drug interactions associated with this medication?

      If Imitrex injection is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Imitrex injection with the following: certain antidepressants (such as fluoxetine or venlafaxine), ergot-containing medicines, or MAOIs.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Imitrex injection during pregnancy are unknown. Imitrex Injection can be found in your breast milk if you take it while breastfeeding. Do not breastfeed for 12 hours after using Imitrex injection. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Imitrex injection should be used only as needed for migraine attacks or cluster headaches.

    • How should I store this medication?

      Store at room temperature. Protect from light.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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