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  • Generic Name: (sumatriptan succinate)
    Other Brands: N/A
  • Last Revised: 07/2014
    • What is this medication and its most common uses?

      Imitrex tablets contain a medicine used to treat migraine attacks with or without aura (vision, hearing, or movement disturbances).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      A migraine occurs when swollen blood vessels in the brain press on nearby nerves. Imitrex tablets work by narrowing those blood vessels, helping to improve your migraine symptoms.

      This medicine is not used to prevent migraine attacks. Always follow the instructions your healthcare provider gave you for preventing migraines.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: In addition to reducing headache pain, Imitrex tablets have been shown to decrease migraine-associated symptoms, such as nausea and sensitivity to light and sound.

      When: Imitrex tablets may relieve your migraine pain within 2 hours.

      How do I know it is working?

      You may feel relief in your migraine headache after you take Imitrex tablets. This is a good indicator that the medicine is working. Recording your headache frequency and medication use may be helpful to you and your healthcare provider in monitoring your progress.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: tingling or numbness of your hands or feet; dizziness; feeling weak, drowsy, or tired; warm or cold feeling; pain, discomfort, or stiffness in your neck, throat, jaw, or chest.

      Less common side effects may include:

      Heart attack or other heart problems, with symptoms such as discomfort in the center of your chest that lasts for more than a few minutes or that goes away and comes back; severe tightness, pain pressure, or heaviness in your chest, throat, neck, or jaw; pain or discomfort in your arms, back, neck, jaw, or stomach; shortness of breath with or without chest discomfort; breaking out in a cold sweat; nausea or vomiting; or lightheadedness.

      Bleeding in the brain or stroke, with symptoms such as numbness or weakness in your face, arm, or leg, especially on one side of your body; confusion; problems speaking or understanding; problems seeing in one or both of your eyes; problems walking; dizziness; loss of balance or coordination; or severe headache with no known cause.

      Stomach or intestinal problems, with symptoms such as sudden or severe stomach pain, stomach pain after meals, weight loss, nausea or vomiting, constipation or diarrhea, bloody diarrhea, or fever.

      Problem with blood circulation to your legs or feet, with symptoms such as cramping and pain in your legs or hips; feeling of heaviness or tightness in your leg muscles; burning or aching pain in your feet or toes while resting; cold feeling or color changes in one or both legs or feet; or numbness, tingling, or weakness in your legs.

      Serotonin syndrome (a potentially life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by the nerve cells) with symptoms such as mental status changes (such as agitation or hallucinations), an increase in your heart rate and body temperature, changes in blood pressure, lack of coordination, overactive reflexes, muscle rigidity, nausea, vomiting, or diarrhea.

      Imitrex tablets may also cause arrhythmias (a life-threatening irregular heartbeat), seizures, or increase your blood pressure.

      Serious allergic reaction with symptoms such as hives or swelling of your tongue, mouth, or throat.

    • Who should not take this medication?

      Do not take Imitrex tablets if you are allergic to them or any of their ingredients.

      Do not take Imitrex tablets if you have a history of heart problems, stroke or "mini-stroke," problems with your blood circulation, or narrowing of blood vessels to your legs, arms, stomach, or kidneys. Do not take Imitrex tablets if you have high blood pressure that is not controlled with medications.

      Do not take Imitrex tablets if you have taken similar medicines (such as almotriptan or eletriptan) or ergot-containing medicines (such as dihydroergotamine or methysergide) within the last 24 hours.

      Do not take Imitrex tablets if you take or have taken monoamine oxidase inhibitors (MAOIs) (such as phenelzine or tranylcypromine), a class of medications used to treat depression and other psychiatric conditions, within the last 2 weeks.

      Do not take Imitrex tablets if you have certain types of migraines known as hemiplegic or basilar migraines, or severe liver problems.


    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Imitrex tablets. Also, talk to your healthcare provider about your complete medical history, especially if you have heart, liver, or kidney problems; high blood pressure; high cholesterol; diabetes; seizures; a family history of heart disease or stroke; are not using effective birth control; if you smoke or are overweight; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is 25 milligrams (mg), 50 mg, or 100 mg, as directed by your healthcare provider. If the migraine comes back or you only get some relief from your migraine, you can take a second dose 2 hours after the first dose. Do not take more than 200 mg in 24 hours.

      If you have mild to moderate liver impairment, your healthcare provider will adjust your dose appropriately.

    • How should I take this medication?

      Take Imitrex tablets exactly as prescribed by your healthcare provider. Do not change your dose without first talking to your healthcare provider.

    • What should I avoid while taking this medication?

      Do not drive a car, operate heavy machinery, or engage in other activities that require you to be alert until you know how Imitrex tablets affect you.

    • What are the possible food and drug interactions associated with this medication?

      If Imitrex tablets are taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Imitrex tablets with the following: certain antidepressants (such as fluoxetine or venlafaxine), ergot-containing medicines, or MAOIs.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Imitrex tablets during pregnancy and breastfeeding are unknown. Do not breastfeed for 12 hours after taking Imitrex tablets. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Imitrex tablets should be taken only as needed for migraine attacks.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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