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  • Generic Name: (miltefosine)
    Other Brands: N/A
  • Last Revised: 10/2014
    • What is this medication and its most common uses?

      Impavido is a medicine used to treat certain types of leishmaniasis (a disease caused by certain protozoan parasites) of your organs, skin, nose, mouth, or throat.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Impavido is thought to work by stopping the growth of protozoa.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: In clinical studies, Impavido was shown to significantly cure all lesions.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider’s directions. It is important that you take Impavido exactly as your healthcare provider has prescribed, for the full course of treatment.

      How do I know it is working?

      You may start to notice an improvement in your symptoms or lesions. This is a good indicator that your medication is working. Your healthcare provider may ask you questions and order tests to assess how well your infection is being treated.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Impavido can cause serious and life-threatening birth defects if taken during pregnancy. Women who can become pregnant should use effective birth control during treatment with Impavido and for 5 months after stopping Impavido treatment. Your healthcare provider will order a pregnancy test before you start your treatment with Impavido. If you become pregnant while taking Impavido, tell your healthcare provider right away.

      More common side effects may include: nausea, vomiting, diarrhea, abdominal (stomach area) pain, decreased appetite, dizziness, headache, sleepiness, skin itching.

      Less common side effects may include:

      Stomach problems with symptoms such as vomiting, diarrhea, or dehydration.

      Low platelet (a type of blood cells that form clots to help stop bleeding) counts.

      Serious skin problems with symptoms such as a skin rash with blisters.

      Impavido may also cause kidney and liver problems.

    • Who should not take this medication?

      Do not take Impavido if you are allergic to it or any of its ingredients.

      Do not take Impavido if you are pregnant.

      Do not take Impavido if you have a condition called Sjogren-Larsson Syndrome.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Impavido. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or liver problems, if you are taking oral contraceptives, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults and children ≥12 years: Your healthcare provider will prescribe the appropriate dose for you or your child, based on the body weight.

    • How should I take this medication?

      Take Impavido exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Impavido without first talking to your healthcare provider.

      Take Impavido capsules whole with food. Do not break, crush, dissolve, or chew the capsules.

    • What should I avoid while taking this medication?

      Do not skip doses. Skipping doses or not completing the full course of Impavido can decrease its effectiveness.

      Do not become pregnant or breastfeed while you are taking Impavido, and for 5 months after stopping treatment with Impavido.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Impavido at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      Impavido can harm your unborn baby if taken during pregnancy. Do not become pregnant or breastfeed while you are taking Impavido. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Impavido, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from moisture.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.