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  • Generic Name: (telaprevir)
    Other Brands: N/A
  • Last Revised: 03/2014
    • What is this medication and its most common uses?

      Incivek is a medicine used in combination with peginterferon alpha and ribavirin to treat chronic (long-term) hepatitis C infection in people with stable liver problems who either have not been treated before or who have failed previous interferon-based treatment.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Incivek works by lowering the ability of the virus to multiply in your body, thereby helping to stop the virus from spreading.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: 79% of people treated with Incivek in combination with peginterferon alpha and ribavirin achieved sustained virologic response, which means that the chronic hepatitis C virus can no longer be found in the blood within a certain time after the end of treatment.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Incivek exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Incivek combination treatment may cause serious and possibly life-threatening skin reactions. Call your healthcare provider immediately if you develop a skin rash, with or without itching; fever; swelling of your face; blisters or skin lesions; mouth sores or ulcers; or red or inflamed eyes, like "pink eye".

      More common side effects may include: rash, itching, anemia (low red blood cell counts), nausea, diarrhea, anal or rectal problems (including hemorrhoids, discomfort, or itching), changes in your taste, tiredness, vomiting.

      Less common side effects may include:

      Incivek combination treatment may harm your unborn baby if taken during pregnancy. Contact your healthcare provider immediately if you believe or suspect you are pregnant.

    • Who should not take this medication?

      Do not take Incivek if you are allergic to it or any of its ingredients.

      Do not take Incivek if you are pregnant or may become pregnant, or if you are a male whose female partner is pregnant.

      Do not take Incivek if you are currently taking alfuzosin, carbamazepine, cisapride, ergot medicines (such as dihydroergotamine, ergonovine, ergotamine, or methylergonovine), lovastatin, midazolam, phenobarbital, pimozide, phenytoin, rifampin, sildenafil or tadalafil (when used for the treatment of pulmonary arterial hypertension), simvastatin, St. John's wort, or triazolam.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Incivek. Also, talk to your healthcare provider about your complete medical history, especially if you have liver problems other than hepatitis C infection, certain blood problems (such as anemia), hepatitis B infection, HIV infection or any other problems with your immune system, history of gout (severe and painful inflammation of the joints) or high uric acid levels in your blood, had an organ transplant, plan to have surgery, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is 1125 milligrams (mg) (three 375-mg tablets) twice a day (10-14 hours apart).

    • How should I take this medication?

      Take Incivek exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Incivek without first talking to your healthcare provider.

      Always take Incivek together with peginterferon alpha and ribavirin. Follow your healthcare provider's instructions on how to properly take these medicines.

      Take Incivek with a meal or snack that contains about 20 grams (g) of fat, within 30 minutes before you take each dose of Incivek. Talk to your healthcare provider about examples of food that contain about 20 g of fat.

      Swallow Incivek tablets whole. Do not chew, crush, break, cut, or dissolve the tablets.

      Incivek may reduce the effectiveness of estrogen-based birth controls. If you are a female who can become pregnant or you are a female whose male partner takes these medicines, you must have a negative pregnancy test before starting treatment, each month during treatment, and for 6 months after you or your partner stops taking Incivek. You must use two forms of effective birth control during treatment and for 6 months after stopping treatment with Incivek.

    • What should I avoid while taking this medication?

      Do not take Incivek on an empty stomach. Always take it with food.

      Do not become dehydrated while taking Incivek. Drink plenty of fluids while you are taking Incivek.

      Do not become pregnant, plan to become pregnant, or breastfeed while you are taking Incivek.

    • What are the possible food and drug interactions associated with this medication?

      If Incivek is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Incivek may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Incivek combination treatment may harm your unborn baby. Do not take Incivek if you are pregnant or breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Incivek by less than 6 hours, take it as soon as you remember. However, if you miss a dose by more than 6 hours, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.