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Incivek is a medicine used in combination with peginterferon alpha and ribavirin to treat chronic (long-term) hepatitis C infection in people with stable liver problems who either have not been treated before or who have failed previous interferon-based treatment.
How does this medication work?
Incivek works by lowering the ability of the virus to multiply in your body, thereby helping to stop the virus from spreading.
What are the beneficial effects of this medication and when should I begin to have results?
What: 79% of people treated with Incivek in combination with peginterferon alpha and ribavirin achieved sustained virologic response, which means that the chronic hepatitis C virus can no longer be found in the blood within a certain time after the end of treatment.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Incivek exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may order tests regularly to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Incivek combination treatment may cause serious and possibly life-threatening skin reactions. Call your healthcare provider immediately if you develop a skin rash, with or without itching; fever; swelling of your face; blisters or skin lesions; mouth sores or ulcers; or red or inflamed eyes, like "pink eye".
More common side effects may include: rash, itching, anemia (low red blood cell counts), nausea, diarrhea, anal or rectal problems (including hemorrhoids, discomfort, or itching), changes in your taste, tiredness, vomiting.
Less common side effects may include:
Incivek combination treatment may harm your unborn baby if taken during pregnancy. Contact your healthcare provider immediately if you believe or suspect you are pregnant.
Do not take Incivek if you are allergic to it or any of its ingredients.
Do not take Incivek if you are pregnant or may become pregnant, or if you are a male whose female partner is pregnant.
Do not take Incivek if you are currently taking alfuzosin, carbamazepine, cisapride, ergot medicines (such as dihydroergotamine, ergonovine, ergotamine, or methylergonovine), lovastatin, midazolam, phenobarbital, pimozide, phenytoin, rifampin, sildenafil or tadalafil (when used for the treatment of pulmonary arterial hypertension), simvastatin, St. John's wort, or triazolam.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Incivek. Also, talk to your healthcare provider about your complete medical history, especially if you have liver problems other than hepatitis C infection, certain blood problems (such as anemia), hepatitis B infection, HIV infection or any other problems with your immune system, history of gout (severe and painful inflammation of the joints) or high uric acid levels in your blood, had an organ transplant, plan to have surgery, or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended dose is 1125 milligrams (mg) (three 375-mg tablets) twice a day (10-14 hours apart).
Take Incivek exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Incivek without first talking to your healthcare provider.
Always take Incivek together with peginterferon alpha and ribavirin. Follow your healthcare provider's instructions on how to properly take these medicines.
Take Incivek with a meal or snack that contains about 20 grams (g) of fat, within 30 minutes before you take each dose of Incivek. Talk to your healthcare provider about examples of food that contain about 20 g of fat.
Swallow Incivek tablets whole. Do not chew, crush, break, cut, or dissolve the tablets.
Incivek may reduce the effectiveness of estrogen-based birth controls. If you are a female who can become pregnant or you are a female whose male partner takes these medicines, you must have a negative pregnancy test before starting treatment, each month during treatment, and for 6 months after you or your partner stops taking Incivek. You must use two forms of effective birth control during treatment and for 6 months after stopping treatment with Incivek.
Do not take Incivek on an empty stomach. Always take it with food.
Do not become dehydrated while taking Incivek. Drink plenty of fluids while you are taking Incivek.
Do not become pregnant, plan to become pregnant, or breastfeed while you are taking Incivek.
If Incivek is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Incivek may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
Incivek combination treatment may harm your unborn baby. Do not take Incivek if you are pregnant or breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Incivek by less than 6 hours, take it as soon as you remember. However, if you miss a dose by more than 6 hours, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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