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  • Generic Name: (mecasermin (rdna origin))
    Other Brands: N/A
  • Last Revised: 04/2016
    • What is this medication and its most common uses?

      Increlex is a medicine that contains man-made insulin-like growth factor (IGF-1). It is used to treat children who are very short for their age due to IGF-1 deficiency. Increlex is administered subcutaneously (just below the skin).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Increlex works by replacing the IGF-1 that your child's body is lacking, thereby promoting growth.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: In clinical trials, Increlex was shown to increase growth by an average of 3.15 inches within the first year of treatment. In 2-6 years, children were shown to grow at a rate of 1.9-2.3 inches per year on average.

      When: Everyone responds differently to treatment, so try to be patient and follow the healthcare provider's directions. It is important that you use Increlex exactly as your child's healthcare provider has prescribed.

      How do I know it is working?

      Your child's healthcare provider may measure his/her height regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: low blood sugar, allergic reaction, enlarged tonsils.

      Symptoms of low blood sugar may include: dizziness, tiredness, restlessness, hunger, irritability, trouble concentrating, sweating, nausea, or fast or irregular heartbeat.

      Signs of enlarged tonsils may include: snoring, difficulty breathing or swallowing, sleep apnea (a condition where breathing stops briefly during sleep), or fluid in the middle-ear.

      Less common side effects may include:

      Increased pressure in the brain with symptoms such as changes in your vision, headache, nausea, or vomiting.

      A bone problem called slipped capital femoral epiphysis (an abnormal bone growth that is caused when the top of the upper leg slips apart) with symptoms such as limping or hip or knee pain.

      Injection site reactions with symptoms such as swelling, fat loss or increase, pain, redness, or bruising.

      Increlex may also worsen scoliosis (a curved spine) caused by rapid growth.

      Allergic reactions with symptoms such as a rash or hives.

    • Who should not take this medication?

      Do not use Increlex if your child is allergic to it or any of its ingredients.

      Do not use Increlex if your child has cancer.

      Do not inject Increlex intravenously (through a vein in your arm).

      Do not use Increlex if your child has growth plates in their bones that are closed.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your child's healthcare provider about all prescription, over-the-counter, and herbal medications he/she is taking before beginning treatment with Increlex. Also, talk to your child's healthcare provider about his/her complete medical history, especially if he/she has liver or kidney problems, diabetes, or scoliosis.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Children ≥2 years: Your child's healthcare provider will prescribe the appropriate dose for your child, based on his/her body weight.

    • How should I take this medication?

      Use Increlex exactly as prescribed by your child's healthcare provider. Your child's healthcare provider will teach you how to prepare and inject Increlex properly.

      Inject Increlex under your child's skin shortly (20 minutes) before or after a meal or snack. Skip your child's dose of Increlex if he/she cannot eat for any reason; do not make up for the missed dose.

      Inject Increlex just below the skin in your child's upper arm, upper leg, stomach area, or buttocks. Never inject Increlex into a vein or muscle. Change the injection site for each injection.

      Please review the instructions that came with the prescription on how to properly inject Increlex.

    • What should I avoid while taking this medication?

      Do not give Increlex to your child until your child's healthcare provider shows you how to inject it correctly.

      Do not use Increlex if the solution is cloudy or has particles in it after mixing.

      Do not miss any scheduled follow-up appointments with your child's healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Increlex at this time. However, always tell your child's healthcare provider about any medicines your child takes, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Increlex during pregnancy and breastfeeding are unknown. Tell the healthcare provider immediately if your child is pregnant, plans to become pregnant, or is breastfeeding.

    • What should I do if I miss a dose of this medication?

      If your child misses a dose of Increlex, inject it as soon as you remember (20 minutes before or after a meal or a snack). However, if it is almost time for the next dose, skip the one missed and return to the regular dosing schedule. Do not inject two doses at once.

    • How should I store this medication?

      Store in the refrigerator. Do not freeze. Protect from direct light. Once opened, use within 30 days and discard any remaining medicine.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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