• Required field
  • Generic Name: (lomitapide)
    Other Brands: N/A
  • Last Revised: 06/2016
    • What is this medication and its most common uses?

      Juxtapid is a medicine used along with diet and other cholesterol-lowering medicines in people with homozygous familial hypercholesterolemia to lower your "bad" low-density lipoprotein (LDL) cholesterol, total cholesterol, apolipoprotein B (a protein that carries "bad" cholesterol in the blood), and non-high-density lipoprotein cholesterol (non-HDL-C).

    • What should I know when beginning and continuing on this medication?

      Juxtapid may only be available under a special restricted distribution program called the Juxtapid REMS program. Juxtapid may only be used in patients who are enrolled in and meet all the conditions of this program. Your healthcare provider will explain this program to you. You will likely receive Juxtapid from a specialty pharmacy.

      How does this medication work?

      Juxtapid works by reducing the amount of cholesterol made in the liver by decreasing some of the key building blocks of cholesterol. This lowers LDL cholesterol levels in the blood.

      Taking Juxtapid is not a substitute for following a healthy low-fat and low-cholesterol diet and exercising to lower your cholesterol.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Along with a low-fat diet, Juxtapid has been shown to reduce LDL cholesterol by 40% after 26 weeks of treatment.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.

      How do I know it is working?

      Your healthcare provider may do blood tests to check your cholesterol levels during your treatment with Juxtapid. Appropriate diet and exercise also contribute to your overall heart health and will also affect the results of your blood tests.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Juxtapid can cause liver problems such as increased liver enzymes or increased fat in the liver. Your healthcare provider will likely do blood tests to check your liver before you start therapy, if your dose is increased, and while you take Juxtapid. Tell your healthcare provider if you experience symptoms such as nausea, vomiting, stomach pain that gets worse or does not go away, fever, flu-like symptoms, yellowing of your eyes or skin, or you are more tired than usual.

      Juxtapid is only available through the Juxtapid REMS Program.

      More common side effects may include: diarrhea, nausea, vomiting, indigestion, abdominal (stomach area) pain.

      Less common side effects may include:

      Harm to your unborn baby. Talk to your healthcare provider right away if you become pregnant while taking Juxtapid.

    • Who should not take this medication?

      Do not take Juxtapid if you are allergic to it or any of its ingredients.

      Do not take Juxtapid if you are pregnant or plan to become pregnant.

      Do not take Juxtapid if you have liver problems or liver disease.

      Do not take Juxtapid with certain medicines that affect how the body breaks down Juxtapid. Check with your healthcare provider and/or pharmacist to see if you are taking any of these medications.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Juxtapid. Also, talk to your healthcare provider about your complete medical history, especially if you have liver, kidney, intestine, or bowel problems; drink alcohol; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended starting dose is 5 milligrams once a day. Your healthcare provider may increase your dose as needed, until the desired effect is achieved.

      If you are taking certain other medicines or have kidney or liver problems, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Juxtapid exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Juxtapid without first talking to your healthcare provider.

      Swallow Juxtapid capsules whole. Do not open, crush, dissolve, or chew the capsules.

      Take Juxtapid with a glass of water, without food, at least 2 hours after your evening meal.

      Your healthcare provider may prescribe certain supplements for you while you are taking Juxtapid. Take these as directed by your healthcare provider.

    • What should I avoid while taking this medication?

      Do not become pregnant while you are taking Juxtapid.

      Do not drink grapefruit juice while you are taking Juxtapid.

      Do not drink alcohol while you are taking Juxtapid without first checking with your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Juxtapid is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Juxtapid may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Do not take Juxtapid if you are pregnant or breastfeeding. It is important that women who are able to become pregnant have a negative pregnancy test before starting therapy, and use effective birth control during therapy. The effects of Juxtapid during breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

      If you become pregnant while taking Juxtapid, talk to your healthcare provider about registering with the Pregnancy Exposure Registry. The purpose of this registry is to collect information about the safety of Juxtapid during pregnancy.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Juxtapid, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

      If you miss a dose of Juxtapid for more than one week, call your healthcare provider for instructions before restarting treatment.

    • How should I store this medication?

      Store at room temperature. Protect from moisture.

    • Who should I contact in case of emergency or overdose?
      back to top

      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
  • Terms of Service

    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.