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  • Generic Name: (morphine sulfate)
    Other Brands: N/A
  • Last Revised: 11/2015
    • What is this medication and its most common uses?

      Kadian is a medicine used to treat moderate to severe pain that requires around-the-clock, treatment for an extended period of time.

      Kadian is a federally controlled substance because it has abuse potential.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Kadian is an extended-release medicine (a type of capsule that releases medicine into your body throughout the day). Kadian works in your central nervous system (the brain and spinal cord) and affects the way your body responds to pain.

      Kadian is not used to treat pain that you only have now and then ("as needed").

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Kadian may help manage moderate to severe pain that lasts for a long time by providing around-the-clock pain relief.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Kadian exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may feel an improvement in your pain. This is a good indicator that the medicine is working. Your healthcare provider may also ask you questions from time to time to assess how well your symptoms are controlled with treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Kadian has abuse potential. If you have concerns, talk to your healthcare provider for more information about abuse and addiction. Do not share Kadian with others and take steps to protect Kadian from theft or misuse.

      Serious and life-threatening breathing problems may occur when taking Kadian. Tell your healthcare provider right away if you have trouble breathing; shortness of breath; fast heartbeat; chest pain; swelling of your face, tongue, or throat; extreme drowsiness; or feel faint.

      Keep Kadian in a safe place, away from children. Accidental use may result in serious harm and may be life-threatening.

      More common side effects may include: drowsiness, constipation, nausea.

      Less common side effects may include:

      Sudden fall in your blood pressure with symptoms such as dizziness, lightheadedness, or fainting when rising too quickly from a sitting or lying position.

    • Who should not take this medication?

      Do not take Kadian if you are allergic to it or any of its ingredients.

      Do not take Kadian if you are having an asthma attack, or if you have severe asthma, trouble breathing, or other lung problems.

      Do not take Kadian if you have a bowel blockage or narrowing of your stomach or intestines.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Kadian. Also, talk to your healthcare provider about your complete medical history, especially if you have a head injury; seizures; problems urinating; liver, kidney, or thyroid problems; pancreas or gallbladder problems; a history of drug or alcohol addiction, or mental health problems, or a family history of these problems; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you based on your previous pain medication and the type and severity of your pain.

      It is important that you do not stop taking this medication abruptly. If you need to change or stop taking this medication, it is important that you only do this with the guidance of your healthcare provider.

    • How should I take this medication?

      Take Kadian exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Kadian without first talking to your healthcare provider.

      Take Kadian at the same time every day.

      Swallow Kadian capsules whole. Do not cut, break, chew, crush, dissolve, or inject Kadian.

      If you cannot swallow Kadian capsules, you can open the capsules and sprinkle its contents over a small amount of applesauce and swallow right away without chewing. Rinse your mouth to ensure all the medicine has been swallowed. Do not save any of the apple sauce/medicine mixture for another dose. Immediately flush the empty Kadian capsule and any unused portion of the capsule after the contents have been sprinkled on applesauce.

      When you stop taking Kadian, flush the remaining capsules down the toilet.

    • What should I avoid while taking this medication?

      Do not drive a car, operate heavy machinery, or engage in other dangerous activities until you know how Kadian affects you.

      Do not drink alcohol or take prescription or over-the-counter medicines that contain alcohol while you are taking Kadian.

    • What are the possible food and drug interactions associated with this medication?

      If Kadian is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Kadian may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Kadian may harm your newborn baby if taken during pregnancy. Kadian can be found in your breast milk if you take it while breastfeeding. Do not take Kadian while you are breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Kadian, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from light and moisture.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.