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  • Generic Name: (alogliptin/metformin hydrochloride)
    Other Brands: N/A
  • Last Revised: 05/2016
    • What is this medication and its most common uses?

      Kazano is a medicine used along with diet and exercise to help control high blood sugar in adults with type 2 diabetes. Kazano contains two medicines that work in two different ways to lower your blood sugar levels: alogliptin and metformin.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Alogliptin helps your body release more insulin. Metformin helps your body respond better to the insulin it makes naturally, decreasing the amount of sugar your liver makes, and decreasing the amount of sugar your intestines absorb. Together, they help to control your blood sugar.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Lowering your blood sugar to a normal level may prevent or delay potential complications associated with diabetes, such as blindness, kidney failure, or heart problems. Also, the combination of medicines in Kazano provides better control of blood sugar compared to either alogliptin or metformin alone.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Kazano exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Check your blood sugar regularly and as your healthcare provider tells you to. Your healthcare provider will also do regular blood tests to measure your blood sugar levels and your hemoglobin A1C (measures your average blood sugar levels over a 2- to 3-month period). Stay on your prescribed diet and exercise program, as this will also affect the results of your blood tests.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Kazano can cause a rare but serious condition called lactic acidosis (a build-up of an acid in the blood). This is a medical emergency and must be treated in the hospital. Stop taking Kazano and call your healthcare provider right away if you feel very weak or tired; have unusual muscle pain, trouble breathing, sleepiness or you sleep longer than usual; develop sudden stomach or intestinal problems with nausea, vomiting, or diarrhea; feel cold, especially in your arms and legs; experience dizziness or lightheadedness; or have a slow or irregular heartbeat.

      You have a higher chance of getting lactic acidosis if you have severe kidney problems or if your kidneys are affected by certain x-ray tests that use injectable dye, have liver problems; drink alcohol very often or drink a lot of alcohol in a short time period; become dehydrated (lose a large amount of body fluids); undergo surgery; or experience a heart attack, severe infection, or stroke.

      More common side effects may include: upper respiratory infection, stuffy or runny nose and sore throat, diarrhea, increase in your blood pressure, headache, back pain, urinary tract infection.

      Less common side effects may include:

      Pancreatitis (inflammation of the pancreas) with symptoms such as pain in your abdomen (stomach area) that is severe and will not go away. You may feel the pain going from your abdomen through to your back and may experience vomiting.

      Heart failure, with symptoms such as increasing shortness of breath or trouble breathing especially when lying down; an unusually fast increase in weight; or swelling of feet, ankles, or legs.

      Serious allergic reactions with symptoms such as rash; hives; and swelling of your face, lips, tongue, or throat that may cause trouble breathing.

      Liver problems, with symptoms such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, and yellowing of your skin or the whites of your eyes.

      Low blood sugar with symptoms such as shaking, sweating, rapid heartbeat, changes in your vision, hunger, headache, or changes in your mood. Your risk of low blood sugar is higher if you eat too little, drink alcohol, or take other medicines to lower your blood sugar.

      Kazano may lower vitamin B12 levels in your blood. Your healthcare provider may check your vitamin B12 blood levels periodically while you are taking Kazano.

      Kazano may cause severe joint pain.

    • Who should not take this medication?

      Do not take Kazano if you are allergic to it or any of its ingredients.

      Do not take Kazano if you have severe kidney problems.

      Do not take Kazano if you have metabolic acidosis (a condition in which there is too much acid in the body).

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Kazano. Also, talk to your healthcare provider about your complete medical history, especially if you have pancreatitis, gallstones (stones in your gallbladder), or heart, kidney, or liver problems; drink alcohol frequently or drink a lot of alcohol in a short time period; plan to have surgery; are going to receive an injection of dye or contrast agents for an x-ray procedure; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you based on your previous diabetes medication, and may adjust your dose as needed, until the desired effect is achieved.

      If you are also using insulin or taking another diabetes medicine called a sulfonylurea (such as glimepiride, glipizide, or glyburide), your healthcare provider may adjust the dose of that medicine.

      If your body is under some types of stress such as a fever, infection, trauma (such as from a car accident), or surgery, your healthcare provider may need to adjust your diabetes medicine.

    • How should I take this medication?

      Take Kazano exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Kazano without first talking to your healthcare provider.

      Take Kazano twice a day. Take it with food to lower your chance of having an upset stomach.

      Swallow Kazano tablets whole. Do not break or cut the tablets.

    • What should I avoid while taking this medication?

      Do not drink excessive amounts of alcohol while taking Kazano. Alcohol can increase your chance of developing lactic acidosis.

    • What are the possible food and drug interactions associated with this medication?

      If Kazano is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Kazano may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Kazano during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Kazano, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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