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  • Generic Name: (lenvatinib)
    Other Brands: N/A
  • Last Revised: 06/2016
    • What is this medication and its most common uses?

      Lenvima is a medicine used to treat a type of thyroid cancer called differentiated thyroid cancer that can no longer be treated with radioactive iodine and is progressing. Lenvima is also used along with another medicine called everolimus to treat advanced kidney cancer, after one course of treatment with another anti-cancer medicine.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Lenvima is thought to work by slowing or stopping the growth of cancer cells in the body.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: By stopping the growth of cancer cells, Lenvima may help to relieve your symptoms associated with cancer.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Lenvima exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Thyroid Cancer

      More common side effects may include: high blood pressure; tiredness; diarrhea; joint and muscle pain; decreased appetite; weight loss; nausea; mouth sores; headache; vomiting; rash, redness, itching, or peeling of your skin on your hands and feet; protein in your urine; abdominal (stomach area) pain; hoarseness.

      Kidney Cancer

      More common side effects may include: diarrhea; tiredness; joint and muscle pain; decreased appetite; vomiting; nausea; mouth sores; high blood pressure; swelling in your arms and legs; cough; abdominal pain; trouble breathing; rash; weight loss; bleeding; protein in your urine.

      Less common side effects may include:

      Heart problems, with symptoms such as shortness of breath or swelling of your ankles.

      Problems with blood clots in your blood vessels (arteries), with symptoms such as severe chest pain or pressure; pain in your arms, back, neck, or jaw; shortness of breath; numbness or weakness on one side of your body; trouble talking; sudden severe headache; or sudden vision change.

      Liver problems, with symptoms such as yellowing of your skin or the whites of your eyes, dark-colored urine, or light-colored stools.

      Bleeding, with symptoms such as severe and persistent nose bleeds, vomiting blood, red or black stools, coughing up blood or blood clots, or heavy or new onset vaginal bleeding.

      May harm your unborn baby. Tell your healthcare provider immediately if you are pregnant or plan to become pregnant.

      Lenvima may cause reversible posterior leukoencephalopathy syndrome (a rare brain disorder with symptoms such as severe headache, seizures, weakness, confusion, blindness, or changes in your vision).

      Lenvima may also cause kidney problems, an opening in the wall of your stomach or intestines (perforation) or an abnormal connection between two parts of your gastrointestinal tract (fistula), changes in the electrical activity of your heart called QT prolongation, low blood calcium levels, or changes in thyroid hormone levels.

    • Who should not take this medication?

      Do not take Lenvima if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Lenvima. Also, talk to your healthcare provider about your complete medical history, especially if you have high blood pressure, heart problems, a history of blood clots in your arteries (including stroke), heart attack, change in vision, a history of a tear in your stomach or intestine, a history of a fistula, headaches, seizures, vision problems, or any bleeding problems; have or have had kidney or liver problems; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Thyroid Cancer

      Adults: The recommended dose is 24 milligrams (mg) (two 10-mg capsules and one 4-mg capsule) once a day.

      Kidney Cancer

      Adults: The recommended dose is 18 mg (one 10-mg capsule and two 4-mg capsules) once a day.

      If you have certain other conditions, or kidney or liver impairment, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Lenvima exactly as prescribed by your healthcare provider.

      Take Lenvima with or without food, at the same time each day.

      If you cannot swallow Lenvima capsules whole, use a medicine cup to measure about one tablespoon of water or apple juice and place into a small glass. Place the capsules into the small glass without breaking or crushing them. Leave the capsules in the liquid for at least 10 minutes, then stir the contents of the glass for at least 3 minutes, and drink the mixture. After drinking, rinse the glass with a small amount of additional water or apple juice and swallow the liquid.  

      It is important that you use effective contraception during treatment with Lenvima and for at least 2 weeks following completion of therapy. Lenvima may cause fertility problems in males and females. Talk to your healthcare provider if this is a concern for you.

    • What should I avoid while taking this medication?

      Do not change your dose or stop taking Lenvima without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Lenvima at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      Lenvima can harm your unborn baby if you take it during pregnancy. Do not breastfeed while you are taking Lenvima. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Lenvima, take it as soon as you remember. However, if your next dose is due within 12 hours, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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