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  • Generic Name: (nitrofurantoin macrocrystals)
    Other Brands: Macrodantin
  • Last Revised: 03/2014
    • What is this medication and its most common uses?

      Macrodantin is an antibiotic used to treat urinary tract infections.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Macrodantin works by killing bacteria, thereby treating your infection. Macrodantin does not treat viral infections, such as the common cold.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Macrodantin has been shown to be effective against various types of bacteria that can cause a urinary tract infection.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Macrodantin exactly as your healthcare provider has prescribed for the full course of treatment, even if your symptoms improve earlier.

      How do I know it is working?

      You may start to notice an improvement in your symptoms. This is a good indicator that your medication is working. Your healthcare provider may ask you questions and order tests to assess how well your infection is being treated.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: allergic reactions, nausea, vomiting, loss of appetite.

      Less common side effects may include:

      Life-threatening lung problems, especially if you receive therapy for six months or longer, with symptoms such as fever, chills, cough, chest pain, or shortness of breath.

      Liver problems, with symptoms such as unexplained nausea or vomiting, stomach pain, fever, weakness, tenderness, itching, unusual tiredness, loss of appetite, light-colored bowel movements, dark-colored urine, or yellowing of your skin or the whites of your eyes.

      Watery and bloody stools (with or without stomach cramps and fever), even as late as two or more months after having taken the last dose of Macrodantin.

      Macrodantin may also cause peripheral neuropathy (numbness, pain, or tingling in your hands or feet) or optic neuritis (inflammation of the optic nerve that causes blurring, graying, or loss of vision).

    • Who should not take this medication?

      Do not take Macrodantin if you are allergic to it or any of its ingredients.

      Do not take Macrodantin if you have anuria (inability to produce urine), oliguria (do not produce enough urine), or kidney problems.

      Do not take Macrodantin if you are at the end of your pregnancy (38-42 weeks).

      Do not take Macrodantin if you have experienced liver problems or yellowing of your skin or the whites of your eyes with previous treatment with nitrofurantoin (main ingredient in Macrodantin).

      Do not give Macrodantin to newborn babies <1 month of age.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Macrodantin. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney, liver, or lung problems; anemia (low red blood cell counts); diabetes; glucose-6-phosphate dehydrogenase (G6PD) deficiency (lack of an enzyme responsible for the breakdown of red blood cells); or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is 50 to 100 milligrams four times a day.

      Children ≥1 month: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her weight.

      Your healthcare provider may adjust your or your child's dose, depending on your needs.

    • How should I take this medication?

      Take Macrodantin exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Macrodantin without first talking to your healthcare provider.

      Take Macrodantin with food.

    • What should I avoid while taking this medication?

      Do not skip doses. Skipping doses or not completing the full course of Macrodantin can decrease its effectiveness and can lead to the growth of bacteria that are resistant to the effects of Macrodantin.

    • What are the possible food and drug interactions associated with this medication?

      If Macrodantin is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Macrodantin with the following: antacids containing magnesium trisilicate, probenecid, or sulfinpyrazone.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Macrodantin during pregnancy are unknown. Macrodantin can be found in your breast milk if you take it while breastfeeding. Do not breastfeed while you are taking Macrodantin. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Macrodantin, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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