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  • Generic Name: (hydroxyprogesterone caproate)
    Other Brands: N/A
  • Last Revised: 03/2016
    • What is this medication and its most common uses?

      Makena is a medicine that contains a progestin hormone. Makena is used to lower the risk of delivering a baby too early (preterm birth) in women who are pregnant with one baby and who have delivered one baby too early in the past. Makena is an injection given intramuscularly (injected into the muscle).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      It is not known exactly how Makena works to prevent preterm birth.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Studies have shown that a lower number of women who received Makena delivered babies at less than 37 weeks of pregnancy.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions.

      How do I know it is working?

      Your healthcare provider may perform blood tests and check your pregnancy during your treatment with Makena.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: hives, itching, nausea, diarrhea, injection-site reactions (such as pain, swelling, itching, bruising, or a hard bump).

      Less common side effects may include:

      Blood clots with symptoms such as leg swelling, redness in your leg, a spot on your leg that is warm to touch, or leg pain that worsens when you bend your foot.

      Allergic reactions with symptoms such as hives, itching, and swelling of the face.

      Yellowing of your skin or the whites of your eyes.

      Makena may also cause fluid retention and increase blood pressure.

    • Who should not take this medication?

      Your healthcare provider will not give you Makena if you are allergic to it or any of its ingredients.

      Your healthcare provider will not give you Makena if you have a history of blood clots or other blood clotting problems.

      Your healthcare provider will not give you Makena if you have a history of certain types of cancers (including breast cancer).

      Your healthcare provider will not give you Makena if you have unusual vaginal bleeding.

      Your healthcare provider will not give you Makena if you have liver problems (including yellowing of your skin or liver tumors).

      Your healthcare provider will not give you Makena if you have high blood pressure that is not controlled.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Makena. Also, talk to your healthcare provider about your complete medical history, especially if you have preeclampsia (high blood pressure and too much protein in your urine), seizures, migraine headaches, asthma, heart or kidney problems, diabetes, a history of depression, high blood pressure, or an allergy to castor oil.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adult women: Your healthcare provider will inject Makena into your hip area once a week (every 7 days).

    • How should I take this medication?

      You will start receiving Makena anytime between 16 weeks of your pregnancy up to 20 weeks and 6 days of your pregnancy. You will continue to receive Makena injections once a week until week 37 of your pregnancy or until your baby is delivered, whichever happens first.

    • What should I avoid while taking this medication?

      Do not miss any scheduled follow-up appointments with your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Makena at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Makena in women pregnant for less than 16 weeks are unknown. Makena is only used in women pregnant for 16 weeks or longer. Makena can be found in your breast milk if you receive it while breastfeeding. Tell your healthcare provider if you are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Makena should be given under special circumstances determined by your healthcare provider. If you miss receiving your scheduled dose, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Your healthcare provider will store this medication for you.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.