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  • Generic Name: (atovaquone/proguanil hydrochloride)
    Other Brands: N/A
  • Last Revised: 05/2015
    • What is this medication and its most common uses?

      Malarone is a medicine used to prevent and treat malaria. Malarone contains two different medicines: atovaquone and proguanil.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Atovaquone and proguanil are thought to work by inhibiting the growth of the parasite.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: By destroying the parasite, Malarone may help relieve symptoms of malaria or your infection.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Malarone exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may notice an improvement in your condition once you begin using Malarone. This is a good indicator that your medication is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Prevention of Malaria

      More common side effects in adults may include: diarrhea, dreams, mouth ulcers, headache.

      More common side effects in children may include: stomach area pain, headache, cough, vomiting.

      Treatment of Malaria

      More common side effects in adults may include: stomach area pain, nausea, vomiting, headache, diarrhea, weakness, loss of appetite, dizziness.

      More common side effects in children may include: vomiting, itching, diarrhea.

      Less common side effects of Malarone may include:

      Malarone may cause hepatitis (inflammation of the liver) or severe skin reactions.

    • Who should not take this medication?

      Do not take Malarone if you are allergic to it or any of its ingredients.

      Do not take Malarone if you have severe kidney impairment.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Malarone. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or liver problems, blood problems, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Prevention of Malaria

      Adults: The recommended dose is one tablet once a day starting 1-2 days before entering a malaria-endemic area and continued daily during your stay and for 7 days after returning.

      Children ≥11 kilograms: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her body weight.

      Treatment of Malaria

      Adults: The recommended dose is 4 tablets once a day for 3 straight days.

      Children ≥5 kilograms: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her body weight.

    • How should I take this medication?

      Take Malarone exactly as prescribed by your healthcare provider.

      Take Malarone at the same time each day with food or a milky drink.

      If you have difficulty swallowing tablets, Malarone may be crushed and mixed with condensed milk.

      If you vomit within an hour after taking your dose of Malarone, take a repeat dose.

      It is important to wear protective clothing and use insect repellents and bed nets for prevention of malaria.

    • What should I avoid while taking this medication?

      Do not change your dose of Malarone or stop taking it without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Malarone is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Malarone with the following: blood thinners (such as warfarin), indinavir, metoclopramide, rifabutin, rifampin, or tetracycline.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Malarone during pregnancy are unknown. Malarone may be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Malarone, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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