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  • Generic Name: (hydrochlorothiazide/triamterene)
    Other Brands: Maxzide, Maxzide-25
  • Last Revised: 12/2013
    • What is this medication and its most common uses?

      Maxzide is a medicine used to treat high blood pressure or fluid retention in people who develop low blood potassium levels or for whom low blood potassium levels could be dangerous. Maxzide contains two medicines: triamterene and hydrochlorothiazide. Maxzide is available as Maxzide tablets and as Maxzide-25 MG tablets.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Triamterene and hydrochlorothiazide are both water pills and work by eliminating extra fluid and sodium (salt) from your body. Triamterene also helps to reduce the excessive loss of potassium from your body that may occur with hydrochlorothiazide alone. Together, they help to lower your blood pressure and fluid retention.

      What are the beneficial effects of this medication and when should I begin to have results?


      High Blood Pressure: By lowering your blood pressure, Maxzide may lower your risk of a stroke or a heart attack.

      Fluid Retention: By eliminating excess fluid from the body, Maxzide may help alleviate symptoms associated with fluid retention.

      When: Maxzide may start eliminating extra fluid and sodium from your body within a few hours of taking it. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.

      How do I know it is working?

      You may notice a decrease in your blood pressure and fluid retention after you start taking Maxzide. Check your blood pressure regularly. Your healthcare provider will also check your blood pressure at every visit. Following an appropriate diet and exercise plan will also affect your blood pressure results.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Maxzide can cause an abnormal increase in your blood potassium levels. This is more likely to occur if you have kidney problems, diabetes (even without kidney problems), or if you are elderly or severely ill. Your healthcare provider will monitor your blood potassium levels frequently during treatment with Maxzide. Tell your healthcare provider right away if you experience tingling or numbness of your hands or feet, muscle weakness, tiredness, or a slow heartbeat.

      More common side effects may include: nausea, constipation, drowsiness, headache, shortness of breath, chest pain, rash.

      Less common side effects may include:

      Temporary nearsightedness (trouble seeing objects farther away) or glaucoma (high pressure in the eye) with symptoms such as changes in your vision or eye pain that may occur within hours to weeks of starting Maxzide.

      Changes in electrolytes (chemicals that are important for the cells in your body to function, such as sodium and potassium) with symptoms such as dry mouth, thirst, weakness, tiredness, drowsiness, restlessness, muscle pains or cramps, muscle tiredness, low or no urine output, fast heartbeat, or nausea and vomiting.

    • Who should not take this medication?

      Do not take Maxzide if you are allergic to it, any of its ingredients, or to other sulfonamide medications (such as sulfamethoxazole).

      Do not take Maxzide if you have kidney problems or are unable to produce urine.

      Do not take Maxzide if you have high blood potassium levels or are taking medicines that can affect your blood potassium levels (such as amiloride, spironolactone, or other medicines containing triamterene). Potassium supplements, potassium-containing salt substitutes, or potassium-enriched diets should also not be used when you are taking Maxzide.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Maxzide. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney, liver, or thyroid problems; diabetes; asthma; lupus (a disease that affects the immune system); gout (severe, painful inflammation of the joints); low folic acid levels in your blood; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Maxzide Tablets

      Adults: The usual dose is 1 tablet once a day.

      Maxzide-25 MG Tablets

      Adults: The usual dose is 1 or 2 tablets once a day.

    • How should I take this medication?

      Take Maxzide exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Maxzide without first talking to your healthcare provider.

    • What should I avoid while taking this medication?

      Do not take potassium supplements, use salt substitutes that contain potassium, or eat a potassium-enriched diet while you are taking Maxzide.

    • What are the possible food and drug interactions associated with this medication?

      If Maxzide is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Maxzide with the following: amiloride, certain blood pressure/heart medications (such as enalapril or lisinopril), lithium, nonsteroidal anti-inflammatory drugs (NSAIDs) (such as indomethacin), or spironolactone.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Maxzide during pregnancy are unknown. Maxzide can be found in your breast milk if you take it while breastfeeding. Do not breastfeed while you are taking Maxzide. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Maxzide, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from light.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
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