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  • Generic Name: (meclofenamate sodium)
    Other Brands: N/A
  • Last Revised: 08/2015
    • What is this medication and its most common uses?

      Meclofenamate capsules belong to a class of medicines called nonsteroidal anti-inflammatory drug (NSAIDs), used to reduce fever and relieve pain. Meclofenamate capsules are also used to relieve signs and symptoms of juvenile arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis (arthritis of the spine), gout attack (severe and painful inflammation of the joints), and sudden shoulder pain caused by tendinitis or bursitis (inflammation and pain around the joints). Additionally, meclofenamate capsules are used to treat menstrual pain and heavy menstrual bleeding.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Meclofenamate capsules work by blocking a substance in your body that is involved in causing pain, fever, and inflammation.

      What are the beneficial effects of this medication and when should I begin to have results?


      Pain and Arthritis Symptoms: Meclofenamate capsules have been shown to relieve pain and improve arthritis symptoms such as joint tenderness and morning stiffness.

      Menstrual Symptoms: Meclofenamate capsules have also been shown to relieve menstrual pain and reduce blood flow in women with heavy menstrual bleeding.


      Pain: Meclofenamate capsules have been shown to start reducing pain within one hour of taking a dose.

      Rheumatoid Arthritis and Osteoarthritis: Meclofenamate capsules may start to relieve your symptoms within a few days of starting treatment.

      How do I know it is working?

      You may notice an improvement in your symptoms after you start taking meclofenamate capsules. This is a good indicator that the medicine is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Meclofenamate capsules may increase the risk of a life-threatening heart attack or stroke. This risk may happen early in treatment and may increase with longer use. Call your healthcare provider right away if you develop chest pain, shortness of breath, weakness, or slurred speech while taking meclofenamate capsules.

      Do not take meclofenamate capsules right before or after a heart surgery called a coronary artery bypass graft (CABG).

      Meclofenamate capsules may increase the risk of life-threatening bleeding, ulcers, and tears of the stomach or intestines. These events may occur at any time during treatment and without warning symptoms. Call your healthcare provider right away if you develop stomach pain, indigestion, bloody or tarry stools, or if you vomit blood while taking meclofenamate capsules.

      More common side effects may include: diarrhea, nausea with or without vomiting, abdominal (stomach area) pain, heartburn, gas, rash, headache, dizziness.

      Less common side effects may include:

      Liver problems, with symptoms such as nausea, tiredness, weakness, itching, yellowing of your skin or the whites of your eyes, right upper stomach pain, and flu-like symptoms.

      Serious allergic reactions, with symptoms such as skin rash, blisters, fever, itching, trouble breathing, or swelling of your face or throat.

      Increased risk of heart failure, with symptoms such as shortness of breath, unexplained weight gain, or swelling of your hands and feet.

      Meclofenamate capsules may also cause new or worse high blood pressure, kidney problems, or anemia (low red blood cell counts).

    • Who should not take this medication?

      Do not take meclofenamate capsules if you are allergic to it or any of its ingredients.

      Do not take meclofenamate capsules if you have had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID (such as ibuprofen or naproxen).

      Do not take meclofenamate capsules right before or after heart bypass surgery.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with meclofenamate capsules. Also, talk to your healthcare provider about your complete medical history, especially if you have asthma; high blood pressure; heart failure; kidney or liver problems; a history of ulcers or bleeding in your stomach or intestines; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.


      Adults: The recommended dose is 50 milligrams (mg) every 4 to 6 hours. Your healthcare provider may increase your dose as needed, until the desired effect is achieved.

      Rheumatoid Arthritis and Osteoarthritis

      Adults and adolescents ≥14 years: The usual dose is 200 to 400 mg a day, divided into 3 or 4 equal doses as determined by your healthcare provider. Your healthcare provider may adjust your dose as needed, until the desired effect is achieved.

      Menstrual Pain and Heavy Menstrual Bleeding

      Adults and adolescents ≥14 years: The recommended dose is 100 mg three times a day, for up to six days, starting at the beginning of menstrual bleeding.

      If you are elderly, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take meclofenamate capsules exactly as prescribed by your healthcare provider. Do not change your dose without first talking to your healthcare provider.

      Take meclofenamate capsules with meals or with milk if you experience an upset stomach.

    • What should I avoid while taking this medication?

      Do not take other NSAIDs in combination with meclofenamate capsules without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If meclofenamate capsules are taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining meclofenamate capsules with the following: aspirin, blood pressure/heart medications known as angiotensin-converting enzyme (ACE) inhibitors (such as lisinopril or enalapril), lithium, methotrexate, warfarin, or water pills (such as furosemide or hydrochlorothiazide).

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of meclofenamate capsules during pregnancy and breastfeeding are unknown. Do not take meclofenamate capsules during pregnancy, particularly late pregnancy. Do not breastfeed while you are taking meclofenamate capsules. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of meclofenamate capsules, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from light and moisture.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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