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  • Generic Name: (mesna)
    Other Brands: N/A
  • Last Revised: 01/2015
    • What is this medication and its most common uses?

      Mesnex is a medicine used to reduce the risk of hemorrhagic cystitis (sudden onset of blood in the urine combined with bladder pain and irritative bladder symptoms) in people receiving cancer treatment with a medicine called ifosfamide. Mesnex is available as an intravenous injection (injected into a vein) and tablets.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Mesnex works by protecting against some of the harmful effects of ifosfamide.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Studies show that when Mesnex was given together with ifosfamide, less than 7% of people developed blood in the urine.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider’s directions. Though you may not notice a change in the way you feel, it is very important to keep taking your medicine as prescribed to prevent urinary side effects from treatment with ifosfamide.

      How do I know it is working?

      If you do not experience hemorrhagic cystitis during treatment with ifosfamide, it is likely that Mesnex is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: nausea, vomiting, constipation, decreased blood cell counts, tiredness, fever, loss of appetite, diarrhea, weakness, abdominal (stomach area) pain, headache, hair loss, drowsiness.

      Less common side effects may include:

      Serious allergic reactions, with symptoms such as fever, low blood pressure, fast heartbeat, trouble breathing, nausea, vomiting, muscle or joint pain, or swelling of your face, lips, tongue, or throat.

      Serious skin reactions, including hives, rash, redness, itching, burning sensation, swelling and redness of the mouth and lips, or redness and warmth of your face, neck, and upper chest. 

    • Who should not take this medication?

      You will not receive treatment with Mesnex if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Mesnex. Also, talk to your healthcare provider about your complete medical history.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you based on your height and weight.

    • How should I take this medication?

      Take Mesnex exactly as prescribed by your healthcare provider.

      You will receive Mesnex injection at the time of ifosfamide administration. Then, you will take Mesnex tablets 2 and 6 hours after each dose of ifosfamide as directed by your healthcare provider.

      Drink 1 to 2 liters of fluid each day while you are receiving treatment with Mesnex.

    • What should I avoid while taking this medication?

      Do not miss any scheduled follow-up appointments with your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Mesnex at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Mesnex during pregnancy and breastfeeding are unknown. Do not breastfeed while you are receiving treatment with Mesnex. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Mesnex or vomit within 2 hours of taking it, contact your healthcare provider for advice. Do not take two doses at once.

    • How should I store this medication?

      Store Mesnex tablets at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.