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  • Generic Name: (alprostadil)
    Other Brands: N/A
  • Last Revised: 06/2014
    • What is this medication and its most common uses?

      Muse is a medicine used to treat men with erectile dysfunction. Muse is available as a urethral suppository to be inserted in the urethra.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Muse works by relaxing blood vessels in the penis. By relaxing the blood vessels, Muse increases the blood flow to the penis and helps men with erectile dysfunction get and keep an erection satisfactory for sexual activity.

      What are the beneficial effects of this medication and when should I begin to have results?

      What:Studies have shown that Muse improved a man’s ability to have sexual intercourse. 

      When: When used on an as-needed basis, Muse may start working within 5-10 minutes and may work up to 30-60 minutes. 

      How do I know it is working?

      You may start to notice an improvement in your ability to have sexual intercourse. This is a good indicator that your medication is working. Your healthcare provider may ask you questions from time to time to assess how well your medicine is working and to check for improvement of your condition.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: aching in the penis, testicles, legs, and perineum (the area between the penis and the rectum); warmth or burning sensation in the urethra; redness of the penis.

      Less common side effects may include:

      Sudden drop in blood pressure with symptoms such as dizziness, lightheadedness, or fainting. Stop sexual activity and get medical help right away if you develop chest pain, dizziness, or nausea during sex.

      An erection that lasts many hours. Get medical help right away if you get an erection that lasts more than 4 hours. If this is not treated right away, permanent damage to your penis can occur.

      Muse may also cause swelling of the veins in your legs, lightheadedness, dizziness, or increased heart rate.

    • Who should not take this medication?

      Do not use Muse if you are allergic to it or any of its ingredients.

      Do not use Muse if you have an abnormally formed penis.

      Do not use Muse if you have been advised not to undertake sexual activity.

      Do not use Muse if you have conditions that may result in long-lasting erections (such as sickle cell anemia, leukemia, or tumor of the bone marrow).

      Do not use Muse for sexual intercourse with a pregnant woman, unless a condom is used.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Muse. Also, talk to your healthcare provider about your complete medical history, especially if you have heart problems (such as chest pain, heart failure, irregular heartbeats, or history of a heart attack); low blood pressure or high blood pressure that is not controlled; or a deformed penis shape.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Men: The recommended dose is one suppository, inserted as needed, about 5-10 minutes before expected sexual activity. Do not use more than 2 suppositories in 24 hours.

    • How should I take this medication?

      Use Muse exactly as prescribed by your healthcare provider. Do not change your dose or use Muse more often without first talking to your healthcare provider.

      Please review the instructions that came with your prescription on how to properly use and discard Muse.

    • What should I avoid while taking this medication?

      Do not drive a car, operate heavy machinery, or engage in other dangerous activities while you are using Muse.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Muse at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      Muse is not for use in women.

    • What should I do if I miss a dose of this medication?

      Muse is not for regular use. Use it only before sexual activity as directed by your healthcare provider.

    • How should I store this medication?

      Store in the refrigerator. You may also store at room temperature for up to 14 days. Protect from heat and sunlight.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.