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  • Generic Name: (primidone)
    Other Brands: Mysoline
  • Last Revised: 12/2013
    • What is this medication and its most common uses?

      Mysoline is a medicine used alone or with other medicines to treat certain types of seizures.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Mysoline is thought to help keep electrical signals balanced in the brain.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Mysoline may help to reduce the frequency of seizures.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Mysoline exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may ask you questions from time to time that will help assess how well your symptoms are controlled with treatment. You may also notice a decrease in the number of seizures you normally experience.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: problems with walking and moving and feelings of dizziness, vertigo (a spinning feeling).

      Less common side effects may include:

      Increased suicidal thoughts or actions, with symptoms such as having thoughts about suicide or dying; attempting to commit suicide; new or worse depression, anxiety, or irritability; panic attacks; trouble sleeping; or other unusual changes in your behavior or mood.

      Blood problems, with symptoms such as fever, swollen glands, or sore throat that come and go or do not go away; frequent infections or an infection that does not go away; tiredness; shortness of breath.

      Serious, life-threatening allergic reaction, with symptoms such as skin rash, hives, sores in your mouth, and blistering or peeling skin.

    • Who should not take this medication?

      Do not take Mysoline if you are allergic to it, any of its ingredients, or to a medicine called phenobarbital.

      Do not take Mysoline if you have porphyria (a blood disorder that interferes with how your body produces heme, which is the oxygen-carrying component of your red blood cells).

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Mysoline. Also, talk to your healthcare provider about your complete medical history, especially if you had or have mood problems, depression, suicidal behavior or thoughts, or if you are pregnant, plan to become pregnant, are breastfeeding, or plan to breastfeed.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults and children ≥8 years: The usual starting dose is 100 to 125 milligrams (mg) once a day at bedtime. Your healthcare provider will increase your dose as needed, until the desired effect is achieved.

      Children <8 years: The usual starting dose is 50 mg once a day at bedtime. Your healthcare provider may increase the dose as needed, until the desired effect is achieved.

      It is important that you do not stop taking this medication abruptly. If you need to change or stop taking this medication, it is important that you only do this with the guidance of your healthcare provider.

    • How should I take this medication?

      Take Mysoline exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Mysoline without first talking to your healthcare provider.

    • What should I avoid while taking this medication?

      Do not drive a car, operate heavy machinery, or engage in other dangerous activities until you know how Mysoline affects you.

      Do not drink alcohol or take other medications that cause dizziness or sleepiness without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Mysoline at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Mysoline during pregnancy are unknown. Mysoline can be found in your breast milk if taken while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

      If you become pregnant while taking Mysoline, talk to your healthcare provider about registering with the North American Antiepileptic Drug (NAAED) Pregnancy Registry. The purpose of this registry is to collect information about the safety of seizure medicines during pregnancy.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Mysoline, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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