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  • Generic Name: (memantine hydrochloride)
    Other Brands:
  • Last Revised: 08/2014
    • What is this medication and its most common uses?

      Namenda XR is a medicine used to treat moderate to severe dementia (an illness involving confusion, loss of memory, and impaired judgment) in people with Alzheimer's disease.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Namenda XR is an extended-release medicine (a type of capsule that releases medicine into your body throughout the day). It works by decreasing abnormal activity in the brain, thereby helping to improve your symptoms of Alzheimer‘s disease.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: When used with another Alzheimer's medicine known as an acetylcholinesterase inhibitor (such as donepezil, galantamine, or rivastigmine), Namenda XR has been shown to improve the ability to perform activities of daily living, as well as help with cognition, which includes elements of attention, memory, and social interaction.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Namenda XR exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You or your caregiver may notice an improvement in your condition. Your healthcare provider may ask you or your caregiver a series of questions from time to time that will help assess how well your symptoms are controlled with treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: headache, diarrhea, dizziness.

      Less common side effects may include:

      Certain medical conditions may affect the amount of Namenda XR in your body and possibly increase the risk of side effects. Talk to your healthcare provider if you have renal tubular acidosis (a disease that occurs when the kidneys fail to excrete acids into the urine, which causes a person's blood to remain too acidic) or a severe urinary tract infection.

    • Who should not take this medication?

      Do not take Namenda XR if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Namenda XR. Also, talk to your healthcare provider about your complete medical history, especially if you have liver or kidney problems.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended starting dose is 7 milligrams once a day. Your healthcare provider may increase your dose as needed, until the desired effect is achieved.

      If you have severe kidney impairment, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Namenda XR exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Namenda XR without first talking to your healthcare provider.

      Take Namenda XR with or without food.

      Namenda XR capsules can be swallowed whole or may be opened, sprinkled on applesauce and the entire contents swallowed.

      Except when opened and sprinkled on applesauce, swallow Namenda XR capsules whole. Do not crush, divide, or chew the capsules.

    • What should I avoid while taking this medication?

      Do not divide the dose of Namenda XR when you sprinkle the contents of the capsule on applesauce. Swallow the entire contents of the capsule with the applesauce.

    • What are the possible food and drug interactions associated with this medication?

      If Namenda XR is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Namenda XR with the following: amantadine, carbonic anyhydrase inhibitors (such as acetazolamide or methazolamide), cimetidine, dextromethorphan, hydrochlorothiazide, ketamine, metformin, nicotine, quinidine, ranitidine, or sodium bicarbonate.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Namenda XR during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a single dose of Namenda XR, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

      If you miss several doses of Namenda XR, contact your healthcare provider before taking your next dose.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.