The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Naprelan may increase your chance of a life-threatening heart attack or stroke. The risk of heart attack or stroke may happen early in treatment and may increase with increasing doses of NSAIDs and with longer use of NSAIDs. Do not take Naprelan right before or after a heart surgery called a coronary artery bypass graft (CABG). Avoid taking Naprelan after a recent heart attack, unless your healthcare provider tells you to. You may have an increased risk of another heart attack if you take NSAIDs after a recent heart attack. Contact your healthcare provider right away if you have any symptoms of a heart attack or stroke, such as chest pain, shortness of breath, weakness, or slurred speech.
Naprelan may increase your chance of bleeding, ulcers, and tears of the esophagus (tube leading from the mouth to the stomach), stomach, and intestines at any time during your treatment. Ulcers, bleeding, and tears can happen without warning symptoms and may be life threatening. Your chance of getting an ulcer or bleeding increases with past history of stomach ulcers, or stomach or intestinal bleeding with use of NSAIDs; use of steroid medicines, blood thinners, and certain antidepressant medicines; more frequent or longer use of NSAIDs; drinking alcohol; having poor health; advanced liver disease; bleeding problems; smoking; and older age. Contact your healthcare provider if you experience sudden or severe stomach pain, indigestion, or bloody diarrhea, or if you vomit blood.
More common side effects may include: indigestion, flu-like symptoms.
Less common side effects may include:
Liver problems with symptoms such as nausea, tiredness, weakness, diarrhea, itching, yellowing of your skin or the whites of your eyes, right upper abdominal (stomach area) pain, and flu-like symptoms.
Serious allergic reactions or serious skin reactions that may be life threatening, with symptoms such as skin rash, blisters with fever, trouble breathing, or swelling of your face or throat.
Naprelan may also cause asthma attacks (in people who have asthma), new or worse high blood pressure, heart failure from body swelling (fluid retention), kidney problems, or anemia (low red blood cell counts).