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  • Generic Name: (phenelzine sulfate)
    Other Brands: N/A
  • Last Revised: 06/2014
    • What is this medication and its most common uses?

      Nardil is a medicine called a monoamine oxidase inhibitor (MAOI). It is used to treat symptoms of depression in people who have not responded to other treatments for depression.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Nardil is thought to work by increasing the activity of certain chemicals in your brain.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: By balancing the chemicals in your brain, Nardil may help improve your symptoms.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Nardil exactly as your healthcare provider has prescribed, even if you do not feel better right away.

      How do I know it is working?

      Your healthcare provider may ask you a series of questions from time to time that will help assess how well your symptoms are controlled with treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Nardil can increase the risk of suicidal thoughts and behavior in children, teenagers, and young adults. Your healthcare provider will monitor you closely for clinical worsening or suicidal/unusual behavior after you start taking Nardil or start a new dose of Nardil. Tell your healthcare provider right away if you experience anxiety, hostility, sleeplessness, restlessness, impulsive or dangerous behavior, thoughts about suicide or dying, or if you have new symptoms or seem to be feeling worse.

      More common side effects may include: dizziness, headache, drowsiness, trouble sleeping, constipation, dry mouth, weight gain, low blood pressure.

      Less common side effects may include:

      Increase in your blood pressure with symptoms such as a headache, increased heart rate, neck stiffness or soreness, nausea, vomiting, sweating (with or without fever), cold or clammy skin, chest pain, or increased sensitivity to light.

    • Who should not take this medication?

      Do not take Nardil if you are allergic to it or any of its ingredients.

      Do not take Nardil if you have pheochromocytoma (a tumor of the adrenal gland), congestive heart failure (a condition in which the heart cannot pump enough blood throughout the body), severe kidney impairment, or liver disease.

      Do not take Nardil if you are currently taking meperidine.

      Do not take Nardil if you are taking dextromethorphan or certain narcotic painkillers.

      Do not take Nardil if you are taking certain other medications (such as amphetamines, cocaine, methylphenidate, dopamine, epinephrine, or norepinephrine).

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Nardil. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or liver problems, bipolar disease, high blood pressure, are scheduled for surgery, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended starting dose is one tablet (15 milligrams) three times a day. Your healthcare provider may adjust your dose as needed, until the desired effect is achieved.

    • How should I take this medication?

      Take Nardil exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Nardil without first talking to your healthcare provider.

      It is important that you follow any dietary recommendations your healthcare provider gives you.

    • What should I avoid while taking this medication?

      Do not drive a car, operate heavy machinery, or engage in other dangerous activities until you know how Nardil affects you.

      Do not eat tyramine-containing foods (such as aged cheese, beer, wine, fava beans, sauerkraut, yogurt, or fermented or pickled meats and fish) while you are taking Nardil and for two weeks after stopping Nardil.

      Do not drink alcohol while you are taking Nardil.

    • What are the possible food and drug interactions associated with this medication?

      If Nardil is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Nardil may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Nardil during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Nardil, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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