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  • Generic Name: (testosterone)
    Other Brands: N/A
  • Last Revised: 05/2015
    • What is this medication and its most common uses?

      Natesto is a nasal gel that contains testosterone and is used in adult men with hypogonadism (an inability of your body to produce enough testosterone).

      Natesto is a federally controlled substance because it has abuse potential.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Natesto works by replacing testosterone, helping to restore normal levels in your body.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Clinical studies have shown that men treated with Natesto had normal levels of testosterone.

      When: Everyone responds differently to treatment so try to be patient and follow your healthcare provider's directions.

      How do I know it is working?

      You may notice an improvement in your symptoms when you start using Natesto. This is a good indicator that the medicine is working. Your healthcare provider may also order tests regularly to check your testosterone levels.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: increased prostate specific antigen levels (a test used to detect prostate cancer), headache, runny nose, nose bleeds, nose pain, sore throat, cough, upper respiratory infection, sinus infection, nose scabs.

      Less common side effects may include:

      Nasal problems with symptoms such as runny nose, congestion, sneezing, nose bleed, nasal discomfort, nasal scabbing, or nasal dryness.

      Worsening of benign prostatic hyperplasia (an enlargement of the prostate gland, which may in turn block the flow of urine), with symptoms such as increased urination at night, trouble starting your urine stream, having to pass urine many times during the day, having an urge that you have to go to the bathroom right away, having a urine accident, being unable to pass urine, or having a weak urine flow.

      Possible increased risk of prostate cancer, heart attack, or stroke.

      Blood clots in your legs or lungs, with symptoms such as pain, swelling, and redness of your legs; or difficulty breathing or chest pain.

      Decreased sperm count, enlarged or painful breasts, or sleep apnea (stopping breathing temporarily during sleep).

      Possible increased risk of liver problems with symptoms such as nausea, vomiting, yellowing of your skin or whites of your eyes, dark urine, or pain in the right side of your stomach area.

      Swelling of your ankles, feet, or body, with or without heart failure.

    • Who should not take this medication?

      Do not use Natesto if you are allergic to it or any of its ingredients.

      Do not use Natesto if you have known or suspected prostate cancer or breast cancer.

      Natesto should not be used by women.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Natesto. Also, talk to your healthcare provider about your complete medical history, especially if you have or have had nose or sinus problems or nasal or sinus surgery; a broken nose within the past 6 months; fracture of your nose that caused the inside of your nose to be crooked; problems with swelling of the lining of your nose; breast cancer; prostate cancer; urinary problems due to an enlarged prostate; heart, liver, or kidney problems; or problems breathing while you sleep.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Men: The recommended dose is 1 pump in each nostril three times a day.

    • How should I take this medication?

      Apply Natesto exactly as prescribed by your healthcare provider. Do not change your dose or stop using Natesto without first talking to your healthcare provider.

      Before using Natesto for the first time, prime your Natesto pump by slowly pressing the pump and releasing it 10 times over a sink. Rinse all the Natesto that comes out when you prime your pump down the sink with warm water.

      If you get any Natesto gel on your hands, wash them with warm water and soap.

      Please review the instructions that came with your prescription on how to properly use and discard Natesto.

    • What should I avoid while taking this medication?

      Do not administer Natesto to any other parts of your body.

      Do not expose women or children to Natesto.

      Do not blow your nose or sniff for 1 hour after using Natesto.

      Do not use other nasal products without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Natesto is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Natesto with the following: blood thinners (such as warfarin), corticosteroids (such as prednisone), or insulin.

    • May I receive this medication if I am pregnant or breastfeeding?

      Natesto is not for use in women.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Natesto, use it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not use two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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