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  • Generic Name: (ofloxacin)
    Other Brands: N/A
  • Last Revised: 08/2014
    • What is this medication and its most common uses?

      Ofloxacin tablets contain an antibiotic used in adults to treat certain bacterial infections such as chronic bronchitis, pneumonia, skin, prostate, cervical, urinary tract, or kidney infections. Ofloxacin tablets may also be used to treat other bacterial infections, as determined by your healthcare provider.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Ofloxacin tablets work by stopping the growth of bacteria, thereby treating your infection.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Ofloxacin tablets may help relieve symptoms of bacterial infections, and may eliminate the bacteria causing the infection.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take ofloxacin tablets exactly as your healthcare provider has prescribed for the full course of treatment, even if your symptoms improve earlier.

      How do I know it is working?

      You may start to notice an improvement in your symptoms. This is a good indicator that your medication is working. Your healthcare provider may ask you questions and order tests to assess how well your infection is being treated.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Ofloxacin tablets can cause tendon (tough cords of tissue that connect muscles to bones) problems (such as rupture or swelling). Some tendon problems include pain, swelling, tears, and inflammation of tendons including the back of the ankle (Achilles), shoulder, hand, or other tendon sites. Your risk of tendon problems while taking ofloxacin tablets is higher if you are over 60 years of age; are taking corticosteroids (such as prednisone); or have had a kidney, heart, or lung transplant. Call your healthcare provider right away at the first sign of tendon pain, swelling, or inflammation. Also, get medical help right away if you hear or feel a snap or pop in a tendon area, bruise right after an injury in a tendon area, or are unable to move the affected area or bear weight.

      Ofloxacin tablets can cause worsening of myasthenia gravis (a disease characterized by long-lasting fatigue and muscle weakness) symptoms. Call your healthcare provider right away if you develop worsening muscle weakness or breathing problems.

      More common side effects may include: nausea, sleeplessness, headache, dizziness, vomiting, diarrhea, rash, itching, vaginal itching/inflammation, taste changes.

      Less common side effects may include:

      Central nervous system effects, such as seizures, hallucinations, restlessness, shaking, anxiousness or nervousness, confusion, depression, trouble sleeping, nightmares, lightheadedness, suspiciousness, or suicidal thoughts or actions.

      Serious allergic reactions, with symptoms such as loss of consciousness; tingling; swelling of your face, lips, tongue, or throat; rash; trouble breathing or swallowing; or rapid heartbeat.

      Damage to the nerves in your arms, hands, legs, or feet, with symptoms such as pain, burning, tingling, numbness, or weakness in any of these areas of your body.

      Watery and bloody stools (with or without stomach cramps and fever), even as late as two or more months after having taken the last dose of ofloxacin tablets.

      Changes in the electrical activity of your heart, with symptoms such as chest pain, fast or slow heartbeat, shortness of breath, and dizziness or fainting.

      Liver damage, with symptoms such as dark colored urine, or yellowing of your skin or the whites of your eyes.

      Low blood sugar levels in people who have diabetes.

    • Who should not take this medication?

      Do not take ofloxacin tablets if you are allergic to them, any of their ingredients, or similar antibiotics (such as ciprofloxacin or levofloxacin).

      Do not take ofloxacin tablets to treat viral infections, such as the common cold.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with ofloxacin tablets. Also, talk to your healthcare provider about your complete medical history, especially if you have tendon, nerve, joint, bone, kidney, or liver problems; myasthenia gravis; rheumatoid arthritis (a type of arthritis that involves inflammation of the joints); seizures; low blood potassium levels; slow heartbeat, or if you or anyone in your family has an irregular heartbeat, especially prolonged QT interval (very fast or abnormal heartbeats), or are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The usual dose is 200 milligrams (mg) to 400 mg every 12 hours.

      Your healthcare provider may prescribe a different dose based on the type of infection you have. If you have kidney impairment and cirrhosis (scarring of your liver), your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take ofloxacin tablets exactly as prescribed by your healthcare provider. Do not change your dose or stop taking ofloxacin tablets without first talking to your healthcare provider.

      Take ofloxacin tablets with or without food at about the same time each day.

      Drink plenty of fluids while you are taking ofloxacin tablets.

    • What should I avoid while taking this medication?

      Do not drive, operate machinery, or engage in other activities that require mental alertness or coordination until you know how ofloxacin tablets affect you.

      Do not expose yourself to sunlamps or tanning beds, and try to limit your time in the sun, as ofloxacin tablets can increase your sensitivity to light. If you need to be outdoors, use sunscreen and wear a hat and loose-fitting clothes that protect your skin from the sun.

      Do not skip doses. Skipping doses or not completing the full course of ofloxacin tablets can decrease its effectiveness and can lead to the growth of bacteria that are resistant to the effects of ofloxacin tablets.

    • What are the possible food and drug interactions associated with this medication?

      If ofloxacin tablets are taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining ofloxacin tablets with the following: antacids, multivitamins, or other medicines or supplements that contain magnesium, aluminum, iron, or zinc; antiarrhythmics (such as amiodarone or sotalol); blood thinners (such as warfarin); diabetes medicines (such as insulin); certain antidepressants such as amoxapine, cimetidine; cyclosporine; didanosine; non-steroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen); probenecid; sucralfate; or theophylline.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of ofloxacin tablets during pregnancy are unknown. The ingredients of ofloxacin tablets may be found in your breast milk if you take them while breastfeeding. Do not breastfeed while you are taking ofloxacin tablets. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of ofloxacin tablets, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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