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  • Generic Name: (tranylcypromine sulfate)
    Other Brands: N/A
  • Last Revised: 09/2016
    • What is this medication and its most common uses?

      Parnate is a medicine called a monoamine oxidase inhibitor (MAOI). It is used to treat major depressive episode in people who have not responded to other treatments for depression.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Parnate is thought to work by increasing the activity of certain chemicals in your brain.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: By balancing the chemicals in your brain, Parnate may help improve your symptoms.

      When: You may begin to feel an improvement within 48 hours to 3 weeks of starting treatment with Parnate. It is important that you take Parnate exactly as your healthcare provider has prescribed, even if you do not feel better right away.

      How do I know it is working?

      Your healthcare provider may ask you a series of questions from time to time that will help assess how well your symptoms are controlled with treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Parnate can increase the risk of suicidal thoughts and behavior in children, teenagers, and young adults. Your healthcare provider will monitor you closely for clinical worsening or suicidal/unusual behavior after you start taking Parnate or start a new dose of Parnate. Tell your healthcare provider right away if you experience anxiety, hostility, sleeplessness, restlessness, impulsive or dangerous behavior, or thoughts about suicide or dying, or if you have new symptoms or seem to be feeling worse.

      More common side effects may include: restlessness, trouble sleeping, weakness, drowsiness, nausea, diarrhea, increased heart rate, loss of appetite, ringing in your ears, muscle spasm, dizziness, dry mouth, stomach pain.

      Less common side effects may include:

      Increase in your blood pressure with symptoms such as a headache, increased heart rate, neck stiffness or soreness, nausea, vomiting, sweating (with or without fever), cold or clammy skin, chest pain, or increased sensitivity to light.

    • Who should not take this medication?

      Do not take Parnate if you are allergic to it or any of its ingredients.

      Do not take Parnate if you have heart, blood vessel, or liver disease; high blood pressure; history of headache; or pheochromocytoma (a tumor of the adrenal gland).

      Do not take Parnate if you take another MAOI (such as furazolidone, isocarboxazid, pargyline, phenelzine, or procarbazine) or certain other antidepressants (such as amitriptyline, clomipramine, desipramine, imipramine, nortriptyline, protriptyline, doxepin, carbamazepine, cyclobenzaprine, amoxapine, maprotiline, or trimipramine). Do not start taking Parnate if you stopped taking any of these medicines within the last week.

      Do not take Parnate if you take a medicine called bupropion (the active ingredient in Wellbutrin, Wellbutrin SR, Wellbutrin XL, and Zyban) or buspirone.

      Do not take Parnate if you take other antidepressant medicines called selective serotonin reuptake inhibitors (SSRIs) (such as fluoxetine, sertraline, or paroxetine) or selective norepinephrine reuptake inhibitors (SNRIs) (such as venlafaxine). Do not start taking Parnate if you stopped taking fluoxetine in the last 5 weeks, stopped taking sertraline or paroxetine in the last 2 weeks, or stopped taking venlafaxine in the last week.

      Do not take Parnate if you take other medicines such as guanethidine, methyldopa, reserpine, dopamine, levodopa, tryptophan, meperidine, or dextromethorphan; medicines that make you sleepy (such as narcotic painkillers and alcohol); or medicines that cause low blood pressure. Do not take Parnate if you consume excessive amounts of caffeine.

      Do not eat tyramine-containing foods (such as matured or aged cheese; aged, cured, or fermented meat, fish, or poultry; fermented soybean products; sauerkraut; fava or broad bean pods, banana peel; concentrated yeast extracts; or tap/draught beers) while you are taking Parnate and for two weeks after stopping Parnate.

      Do not take Parnate if you are scheduled for surgery requiring general anesthesia.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Parnate. Also, talk to your healthcare provider about your complete medical history, especially if you: have kidney or liver problems, bipolar disease, thyroid disease, seizures, diabetes, or high blood pressure; are scheduled for surgery; are pregnant; plan to become pregnant; or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The usual dose is 30 milligrams per day, taken in divided doses as directed by your healthcare provider. Your healthcare provider may adjust your dose as needed, until the desired effect is achieved.

    • How should I take this medication?

      Take Parnate exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Parnate without first talking to your healthcare provider.

      It is important that you follow any dietary recommendations your healthcare provider gives you.

    • What should I avoid while taking this medication?

      Do not drive a car, operate heavy machinery, or engage in other dangerous activities until you know how Parnate affects you.

      Do not drink alcohol or excessive amounts of caffeine while you are taking Parnate.

      Do not take any over the counter medications for cold, allergies, or weight reduction without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Parnate is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Parnate may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Parnate during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Parnate, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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