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  • Generic Name: (lisinopril)
    Other Brands: N/A
  • Last Revised: 10/2016
    • What is this medication and its most common uses?

      Qbrelis is a medicine known as an angiotensin-converting enzyme (ACE) inhibitor, used alone or in combination with other medicines to treat high blood pressure. Qbrelis is also used to reduce the signs and symptoms of heart failure, and to lower the risk of death in people who have just had a heart attack. Qbrelis is available as an oral solution.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Qbrelis works by relaxing and widening your blood vessels, allowing your blood to flow through more smoothly.

      What are the beneficial effects of this medication and when should I begin to have results?


      High Blood Pressure: By lowering your blood pressure, Qbrelis may lower your risk of a stroke or a heart attack.

      Heart Failure: When used in combination with other medicines, Qbrelis has been shown to relieve some of the symptoms associated with heart failure, including shortness of breath and swelling.

      After a Heart Attack: Qbrelis has been shown to improve survival after a heart attack.

      When: Qbrelis may start lowering your blood pressure within a few weeks. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.

      How do I know it is working?

      Check your blood pressure regularly. Your healthcare provider may also check your blood pressure at every visit. Following an appropriate diet and exercise plan will also affect your blood pressure results.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Qbrelis can harm your unborn baby. Talk to your healthcare provider about other ways to lower your blood pressure if you plan to become pregnant. Tell your healthcare provider right away if you become pregnant while taking Qbrelis.

      High Blood Pressure

      More common side effects may include: headache, dizziness, cough.

      Heart Failure

      More common side effects may include: low blood pressure, chest pain.

      After a Heart Attack

      More common side effects may include: low blood pressure.

      Less common side effects of Qbrelis may include:

      Serious allergic reaction with symptoms such as extreme swelling of your face, lips, tongue, throat, or gut (causing severe abdominal [stomach area] pain). You may have an increased risk of experiencing these symptoms if you have a history of angioedema (a condition involving swelling of the face, extremities, eyes, lips, and tongue) or if you are African American.

      Low blood pressure with symptoms such as lightheadedness, especially during the first few days of taking Qbrelis. Dehydration, excessive sweating, diarrhea, or vomiting can also lead to an excessive fall in your blood pressure.

      Liver problems, with symptoms such as yellowing of your skin or the whites of your eyes.

      Qbrelis may also cause kidney problems or increase your blood potassium levels.

    • Who should not take this medication?

      Do not take Qbrelis if you are allergic to it, any of its ingredients, or if you have a history of angioedema related to previous treatment with similar medicines.

      Do not take Qbrelis if you have hereditary or idiopathic angioedema.

      If you are diabetic, do not take Qbrelis in combination with aliskiren.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Qbrelis. Also, talk to your healthcare provider about your complete medical history, especially if you have diabetes; kidney, liver, or heart problems; a history of angioedema; plan to undergo surgery or receive anesthesia; or are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      High Blood Pressure

      Adults: The recommended starting dose is 10 milligrams (mg) once a day. If you are taking a water pill, your healthcare provider may start you on a lower dose of Qbrelis. Your healthcare provider may adjust your dose as needed, until the desired effect is achieved.

      Children ≥6 years: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her weight.

      Heart Failure

      Adults: The recommended starting dose is 5 mg once a day. Your healthcare provider may adjust your dose as needed.

      After a Heart Attack

      Adults: Your healthcare provider will prescribe the appropriate dose for you based on your condition.

      If you have kidney problems, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Qbrelis exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Qbrelis without first checking with your healthcare provider.

    • What should I avoid while taking this medication?

      Do not become dehydrated. Drink adequate amounts of fluids while you are taking Qbrelis.

      Do not take potassium supplements or use salt substitutes that contain potassium without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Qbrelis is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Qbrelis with the following: aliskiren, other blood pressure/heart medications called angiotensin receptor blockers (ARBs) (such as losartan or valsartan), dextran, diabetes medicines (such as insulin), everolimus, injectable gold (sodium aurothiomalate), lithium, nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen or naproxen),  potassium supplements, salt substitutes containing potassium, sirolimus, temsirolimus, or water pills (such as hydrochlorothiazide, spironolactone, or triamterene).

    • May I receive this medication if I am pregnant or breastfeeding?

      Do not take Qbrelis if you are pregnant or breastfeeding. Qbrelis can harm your unborn baby. The effects of Qbrelis during breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Qbrelis, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from freezing and excessive heat.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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