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  • Generic Name: (phentermine/topiramate)
    Other Brands: N/A
  • Last Revised: 11/2014
    • What is this medication and its most common uses?

      Qsymia is a medicine used with a low calorie diet and physical activity for weight loss in people who are obese or have weight-related medical problems. Qsymia contains two medicines that work in two different ways to help weight loss: phentermine and topiramate.

      Qsymia is a federally controlled substance because it has abuse potential.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Qsymia is an extended -release medicine (a type of capsule that releases medicine into your body throughout the day). Phentermine and topiramate are thought to work by reducing appetite, thereby decreasing food consumption and leading to weight loss.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Qsymia has been shown to cause more weight loss when you take it along with dietary management compared to people on dietary management alone.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Qsymia exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may start to notice a reduction in your weight. This is a good indicator that your medication is working. Your healthcare provider may ask you questions from time to time to assess how well your medicine is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: numbness or tingling in your hands, arms, feet, or face; dizziness; changes in your taste; trouble sleeping; constipation; dry mouth.

      Less common side effects may include:

      Increased suicidal thoughts or actions, with symptoms such as having thoughts about suicide or dying; attempting to commit suicide; new or worse depression, anxiety, or irritability; panic attacks; trouble sleeping; feeling agitated or restless; acting aggressive; being angry or violent; acting on dangerous impulses; an extreme increase in activity and talking; or other unusual changes in your behavior or mood.

      Eye problems with symptoms such as severe and persistent eye pain, redness, or changes in your vision.

      Mood changes with symptoms such as depression, anxiety, or trouble sleeping.

      Kidney stones with symptoms such as severe side or back pain or blood in your urine.

      Metabolic acidosis (a condition in which there is too much acid in the body) with symptoms such as feeling tired, loss of appetite, changes in your heartbeat, or trouble thinking clearly.

      Problems with concentration, attention, memory, or speech.

      Decreased sweating and increased body temperature, with symptoms such as high fever, a fever that does not go away, and decreased sweating.

      Qsymia may also cause seizures, increased heart rate, low blood potassium levels, or low blood sugar levels.

      Harm to your unborn baby if taken during pregnancy. Contact your healthcare provider immediately if you believe or suspect you are pregnant while you are receiving Qsymia.

    • Who should not take this medication?

      Do not take Qsymia if you are allergic to it or any of its ingredients.

      Do not take Qsymia if you have hyperthyroidism (an overactive thyroid gland) or glaucoma (high pressure in the eye).

      Do not take Qsymia if you are taking a medication called a monoamine oxidase inhibitor (MAOI) (such as phenelzine or selegiline) or have taken any within the past 14 days.

      Do not take Qsymia if you are pregnant.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Qsymia. Also, talk to your healthcare provider about your complete medical history, especially if you have heart problems (including an abnormal heart rhythm or a history of a heart attack or stroke); kidney problems or are on dialysis; liver problems; seizures; a history of depression, mood problems, or suicidal thoughts or behavior; glaucoma; chronic diarrhea; if you are on a ketogenic diet (a diet high in fat and low in carbohydrates); bone problems; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you, based on your height and body weight.

    • How should I take this medication?

      Take Qsymia exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Qsymia without first talking to your healthcare provider. Stopping Qsymia suddenly can cause serious problems, such as seizures.

      Take Qsymia once a day in the morning with or without food. Drink plenty of fluids while you are taking Qsymia.

      Your healthcare provider should start you on a diet and exercise program when you start Qsymia. Stay on this program while you are taking Qsymia.

    • What should I avoid while taking this medication?

      Do not drive, operate heavy machinery, or engage in other dangerous activities until you know how Qsymia affects you.

      Do not drink alcohol while you are taking Qsymia.

      Do not become pregnant while you are taking Qsymia.

    • What are the possible food and drug interactions associated with this medication?

      If Qsymia is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Qsymia with the following: acetazolamide, alcohol, birth control pills, methazolamide, valproic acid, water pills (such as hydrochlorothiazide), or zonisamide.

    • May I receive this medication if I am pregnant or breastfeeding?

      Qsymia may cause harm to your unborn baby if taken during pregnancy. Qsymia can be found in your breast milk if you take it while breastfeeding. Do not become pregnant or breastfeed while you are taking Qsymia. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Qsymia, skip the one you missed and take your usual dose the following morning. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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