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  • Generic Name: (short ragweed pollen allergen extract)
    Other Brands: N/A
  • Last Revised: 04/2016
    • What is this medication and its most common uses?

      Ragwitek is a medicine used to treat ragweed pollen allergies that can cause sneezing, runny or itchy nose, stuffy or congested nose, or itchy and watery eyes. Ragwitek is available as a sublingual tablet (placed under the tongue).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Ragwitek works by decreasing your body's sensitivity to ragweed pollen.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: In clinical studies, people who began taking Ragwitek about 12 weeks before the start of ragweed pollen season and continued taking it throughout the season experienced less allergy symptoms (such as runny, stuffy or itchy nose; sneezing; or gritty/itchy or watery eyes) during the entire season, including peak season.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Ragwitek exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may notice an improvement in your allergy symptoms after you start taking Ragwitek. This is a good indicator that your medicine is working. Your healthcare provider may ask you questions from time to time to check how well your symptoms are controlled.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Ragwitek can cause severe allergic reactions that may be life threatening. Stop taking Ragwitek and get medical treatment right away if you have any of the following symptoms: trouble breathing, swallowing, or speaking; throat tightness or swelling; dizziness or fainting; rapid or weak heartbeat; severe stomach cramps or pain, vomiting, or diarrhea; or severe flushing or itching of the skin.

      More common side effects may include: itching of the mouth, lips, or tongue; swelling under the tongue; throat irritation.

      Less common side effects may include:

      Eosinophilic esophagitis (a condition that causes inflammation of the esophagus [the tube that connects your mouth and stomach]), with symptoms such as difficulty swallowing or chest pain.

    • Who should not take this medication?

      Do not take Ragwitek if you are allergic to it or any of its ingredients, or if you had a severe allergic reaction in the past that included trouble breathing, dizziness or fainting, or rapid or weak heartbeat.

      Do not take Ragwitek if you have severe, unstable, or uncontrolled asthma.

      Do not take Ragwitek if you have ever been diagnosed with eosinophilic esophagitis.

      Do not take Ragwitek if you have ever had difficulty with breathing due to swelling of the throat or upper airway after using any sublingual immunotherapy before.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Ragwitek. Also, talk to your healthcare provider about your complete medical history, especially if you have asthma, lung disease (such as chronic obstructive pulmonary disease), or heart disease (such as coronary artery disease, irregular heartbeats, or uncontrolled high blood pressure); are unable or unwilling to administer auto-injectable epinephrine to treat a severe allergic reaction to Ragwitek; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is one tablet a day, placed under the tongue. You will begin taking Ragwitek at least 12 weeks before the start of ragweed pollen season and continue taking it throughout the season.

    • How should I take this medication?

      Take Ragwitek exactly as prescribed by your healthcare provider. Do not take more medicine or stop taking Ragwitek without first talking to your healthcare provider.

      You will take the first dose of Ragwitek in your healthcare provider's office. After taking the first dose, your healthcare provider will observe you for at least 30 minutes to monitor you for signs or symptoms of a severe allergic reaction. If you tolerate the first dose of Ragwitek, you will continue taking it at home.

      Take the tablet from the blister pack after carefully removing the foil with dry hands. Place the tablet under your tongue right away, and allow it to completely dissolve. Do not swallow for at least 1 minute.

      Wash your hands after handling Ragwitek tablets.

      Your healthcare provider will prescribe auto-injectable epinephrine, a medicine you can inject if you have a severe allergic reaction after taking Ragwitek.

    • What should I avoid while taking this medication?

      Do not take Ragwitek with food or beverages. You should not eat or drink anything for 5 minutes after taking Ragwitek.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Ragwitek at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Ragwitek during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss one dose of Ragwitek, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

      If you miss more than one dose of Ragwitek, call your healthcare provider before restarting treatment.

    • How should I store this medication?

      Store at room temperature. Store Ragwitek in the original package to protect from moisture until you are ready to take it.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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