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  • Generic Name: (ranolazine)
    Other Brands: N/A
  • Last Revised: 01/2016
    • What is this medication and its most common uses?

      Ranexa is a medicine used alone or with other medication to treat long-term angina (chest pain). Ranexa is an extended-release medicine (a type of tablet that releases medicine into your body throughout the day).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      It is unknown exactly how Ranexa works to relieve chest pain.

      Ranexa is not used to treat an acute angina attack.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Ranexa has been shown to reduce chest pain associated with exercise and reduce angina attacks.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Ranexa exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may feel an improvement in your chest pain after you start taking Ranexa. This is a good indicator that the medicine is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: dizziness, headache, constipation, nausea.

      Less common side effects may include:

      Changes in the electrical activity of your heart with symptoms such as feeling faint or lightheaded or fast, irregular heartbeats.

      Ranexa can also cause or worsen existing kidney problems.

    • Who should not take this medication?

      Do not take Ranexa if you are allergic to it or any of its ingredients.

      Do not take Ranexa if you are taking certain medications such as carbamazepine, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, ritonavir, saquinavir, or St. John's wort.

      Do not take Ranexa if you have liver cirrhosis (scarring of the liver).

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Ranexa. Also, talk to your healthcare provider about your complete medical history, especially if you have a heart problem called "long QT syndrome", liver or kidney problems, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The usual starting dose is 500 milligrams (mg) twice a day. Your healthcare provider may increase your dose as needed, based on your condition and response.

    • How should I take this medication?

      Take Ranexa exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Ranexa without first talking to your healthcare provider.

      Take Ranexa tablets whole, with or without food. Do not crush, break, or chew Ranexa tablets.

    • What should I avoid while taking this medication?

      Do not drink or eat grapefruit juice or grapefruits while you are taking Ranexa.

      Do not drive a car, operate heavy machinery, or engage in other dangerous activities until you know how Ranexa affects you.

    • What are the possible food and drug interactions associated with this medication?

      If Ranexa is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Ranexa may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Ranexa during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Ranexa, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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