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  • Generic Name: (methotrexate)
    Other Brands: N/A
  • Last Revised: 03/2015
    • What is this medication and its most common uses?

      Rasuvo is a medicine used to treat severe psoriasis (an immune disorder that affects the skin) in people who have not responded to other forms of therapy. It is also used to treat rheumatoid arthritis (a type of arthritis that involves inflammation of the joints) (including polyarticular juvenile idiopathic arthritis [arthritis in children]) in people who have not responded to certain other medications. Rasuvo is injected subcutaneously (just below the skin).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Rasuvo is thought work by decreasing the activity of the immune system in the treatment of rheumatoid arthritis and slow the growth of skin cells to stop the formation of scales in psoriasis.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Rasuvo has been shown to improve symptoms associated with arthritis, such as joint swelling and tenderness.


      Rheumatoid Arthritis: Rasuvo may start working to reduce symptoms associated with rheumatoid arthritis within 3 to 6 weeks.

      How do I know it is working?

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Rasuvo can harm your unborn baby. If you are pregnant or your sexual partner is pregnant, or plans to become pregnant, do not receive Rasuvo. Neither you nor your partner should become pregnant while receiving Rasuvo. Women should wait at least 1 menstrual cycle after stopping treatment with Rasuvo before getting pregnant. Men should wait at least 3 months after stopping treatment with Rasuvo before getting their partner pregnant. Women who can become pregnant should have a pregnancy test before receiving Rasuvo.

      Rasuvo can cause serious and life-threatening organ system toxicity, affecting the stomach/intestines, nerve, bone marrow, lung, liver, kidneys, immune system, and skin. Your healthcare provider will do blood tests and other types of tests before you start and during your treatment with Rasuvo. Call your healthcare provider right away if you develop symptoms such as vomiting, neck stiffness, diarrhea, paralysis, mouth sores, irritability, fever, sleepiness, confusion, problems with coordination, weakness, dry cough, temporary blindness, trouble breathing, seizures, severe skin rash, headache, and back pain.

      Rasuvo may cause lymphoma (a type of cancer involving cells of the immune system, called lymphocytes) or certain types of infections.

      Rasuvo may also cause soft tissue and bone damage if you are getting radiation therapy at the same time you are receiving Rasuvo.

      Rasuvo may also cause tumor lysis syndrome (a life-threatening condition characterized by a rapid release of substances from tumor cells into your blood).

      More common side effects may include: nausea, stomach pain, indigestion, mouth sores, rash, stuffy or runny nose or sore throat, diarrhea, vomiting, headache, bronchitis, low blood cell counts, hair loss, dizziness, sensitivity to light, burning skin lesions, lung problems.

      Less common side effects may include:

      Rasuvo may affect your ability to have a baby. Males may have a decreased sperm count, and females may have changes to their menstrual cycle. This can happen while taking Rasuvo and for a short period of time after you stop.

    • Who should not take this medication?

      Your healthcare provider will not administer Rasuvo to you if you are allergic to it or any of its ingredients.

      Your healthcare provider will not administer Rasuvo to you if you are pregnant, plan to become pregnant, or are breastfeeding.

      Your healthcare provider will not administer Rasuvo to you if you have any condition that weakens your immune system.

      Your healthcare provider will not administer Rasuvo to you if your bone marrow does not make enough blood cells; or if you have low white blood cell counts, low platelet counts, or serious anemia.

      Your healthcare provider will not administer Rasuvo to you if you drink alcohol, have liver problems from alcohol abuse, or if you have long-term liver disease.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Rasuvo. Also, talk to your healthcare provider about your complete medical history, especially if you have liver or kidney problems, if you are scheduled to receive a vaccine, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.


      Adults: The recommended starting dose is 10-25 mg injected once a week.

      Rheumatoid Arthritis

      Adults: The recommended starting dose is 7.5 milligrams (mg) injected once a week.

      Polyarticular Juvenile Idiopathic Arthritis

      Children 2-16 years: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her height and weight.

      Your healthcare provider may adjust your or your child's dose as needed, until the desired effect is achieved.

    • How should I take this medication?

      Use Rasuvo exactly as prescribed by your healthcare provider. Do not change your dose or stop using Rasuvo without first talking to your healthcare provider.

      Inject Rasuvo only once a week. Do not use Rasuvo every day.

      Your healthcare provider will show you or your caregiver how to inject Rasuvo.

      Check Rasuvo before you inject it. Rasuvo should be yellow-brown in color and should not have any lumps or particles in it.

      Please read the instructions that came with your prescription on how to properly use and dispose of Rasuvo.

    • What should I avoid while taking this medication?

      Do not inject Rasuvo until you have been trained on the proper way to use it.

      Do not drink alcohol during your treatment with Rasuvo.

      Do not become pregnant or breastfeed during your treatment with Rasuvo.

      Do not drive, operate heavy machinery, or do other dangerous activities until you know how Rasuvo affects you.

      Do not miss any scheduled follow-up appointments with your healthcare provider. Rasuvo may cause serious and life-threatening effects. It is important that you are always under your healthcare provider's supervision during treatment.

    • What are the possible food and drug interactions associated with this medication?

      If Rasuvo is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Rasuvo with the following: aspirin, azathioprine, certain antibiotics (such as chloramphenicol, penicillin, sulfamethoxazole/trimethoprim, or tetracycline), certain cancer medicines (such as cisplatin or mercaptopurine), folic acid supplementation, medicines that reduce acid in your stomach (such as omeprazole or pantoprazole), nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen or naproxen), phenytoin, probenecid, retinoids (such as isotretinoin), sulfasalazine, or theophylline.

    • May I receive this medication if I am pregnant or breastfeeding?

      Do not use Rasuvo during pregnancy or breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Rasuvo should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Store at room temperature. Protect from light.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.