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  • Generic Name: (glycerol phenylbutyrate)
    Other Brands: N/A
  • Last Revised: 10/2016
    • What is this medication and its most common uses?

      Ravicti is a medicine used along with a low protein diet to manage high blood levels of ammonia caused by a condition called urea cycle disorder. Ravicti is available as an oral liquid. Ravicti may also be administered through a feeding tube.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Ravicti works by removing ammonia from the body.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: People treated with Ravicti experienced average blood ammonia levels within a normal range during the treatment year.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions. It is important that you take Ravicti exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order certain tests to check your blood ammonia levels.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: diarrhea, gas, headache.

      Less common side effects may include:

      Nervous system problems, with symptoms such as sleepiness, weakness, lightheadedness, changes in taste, hearing or memory problems, confusion, worsening numbness or tingling in your hands or feet, or headache.

    • Who should not take this medication?

      Do not take Ravicti if you are allergic to it or any of its ingredients.

      Do not give Ravicti to children <2 months of age.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Ravicti. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or liver problems, pancreas or bowel (intestine) problems, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults and children ≥2 years: Your healthcare provider will prescribe the appropriate dose for you based on your condition or previous medicine, and may adjust the dose as needed.

      If you have liver impairment, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Ravicti exactly as prescribed by your healthcare provider.

      Take Ravicti with food.

      Administer Ravicti directly into the mouth with an oral syringe or a dosing cup.

    • What should I avoid while taking this medication?

      Do not change your dose or stop taking Ravicti without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Ravicti is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Ravicti with the following: alfentanil, corticosteroids (such as prednisone), cyclosporine, haloperidol, midazolam, probenecid, quinidine, or valproic acid.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Ravicti during pregnancy and breastfeeding are unknown. Do not breastfeed while you are taking Ravicti. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

      If you become pregnant while taking Ravicti, talk to your healthcare provider about registering with the pregnancy registry associated with Ravicti. The purpose of this registry is to collect information about the health of you and your baby.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Ravicti, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.