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  • Generic Name: (interferon beta-1a)
    Other Brands: N/A
  • Last Revised: 10/2015
    • What is this medication and its most common uses?

      Rebif is a medicine used to treat relapsing forms of multiple sclerosis. Rebif is administered subcutaneously (injected just below the skin).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      It has not yet been proven precisely how Rebif works to successfully treat relapsing forms of multiple sclerosis.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Rebif may decrease the number of flare-ups and slow the occurrence of some of the physical disability associated with the disease.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you use Rebif exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may ask you a series of questions from time to time that will help assess how well your symptoms are controlled with treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: injection-site disorders, flu-like symptoms, abdominal (stomach area) pain, depression, changes in liver blood tests.

      Less common side effects may include:

      Changes in your behavior, such as depression or suicidal thoughts or behaviors.

      Liver problems, with symptoms such as nausea, loss of appetite, yellowing of your skin or the whites of your eyes, confusion, bleeding more easily than normal, tiredness, or dark-colored urine and pale stools.

      Serious allergic reactions, with symptoms such as itching; swelling of your face, eyes, lips, tongue, or throat; trouble breathing; anxiousness; feeling faint; skin rash, hives, or sores in your mouth.

      Injection-site reactions, with symptoms such as redness, pain, swelling, color changes (blue or black), or drainage of fluid.

      Rebif may also cause changes in your blood cell counts (with symptoms such as infections and problems with bleeding and bruising).

    • Who should not take this medication?

      Do not use Rebif if you are allergic to it, any of its ingredients, other types of interferon beta proteins, or to human albumin.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Rebif. Also, talk to your healthcare provider about your complete medical history, especially if you have liver or thyroid problems, bleeding problems or blood clots, low blood cell counts, seizures, mental illness (including depression and suicidal behavior), if you drink alcohol, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is either 22 micrograms (mcg) or 44 mcg three times a week. Your healthcare provider may start you on a lower dose, and may increase your dose as needed.

    • How should I take this medication?

      Use Rebif exactly as prescribed by your healthcare provider. Do not use it more often or stop using it without first talking to your healthcare provider.

      Your healthcare provider may administer the first dose of Rebif to you. Do not attempt to self-inject without proper training from your healthcare provider.

      Rotate injection sites with each injection to lessen the risk of injection-site reactions.

      Please review the instructions that came with your prescription on how to properly use Rebif.

    • What should I avoid while taking this medication?

      Do not inject Rebif into an area of the body where the skin is irritated, bruised, infected, or scarred.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Rebif at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Rebif during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Rebif, use it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not use two doses at once.

    • How should I store this medication?

      Store in the refrigerator. Do not freeze.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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