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Recombinate is a medicine used to prevent and control bleeding episodes in people with hemophilia A (a type of bleeding disorder). It is also used to prevent bleeding during surgical procedures in people with hemophilia A. Recombinate is administered intravenously (directly into your vein).
How does this medication work?
Recombinate works by replacing a clotting factor in your body, thereby helping your blood to form clots and decreasing bleeding episodes.
What are the beneficial effects of this medication and when should I begin to have results?
What: By replacing a clotting factor in your body, Recombinate has been shown to treat bleeding episodes in people with hemophilia A.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider’s directions. It is important that you use Recombinate exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may perform certain tests to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: chills, flushing, rash, nose bleeds.
Less common side effects may include:
Allergic reactions, with symptoms such as dizziness, itching, rash, hives, flushing, face swelling, difficulty breathing, paleness, fever, nausea, low blood pressure, tingling or numbness of your hands or feet, or loss of consciousness.
Recombinate may also cause local tissue irritation.
Do not use Recombinate if you are allergic to it or any of its ingredients.
Do not use Recombinate if you are allergic to mouse, hamster, or cow proteins.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Recombinate. Also, talk to your healthcare provider about your complete medical history, especially if you have been told that you have inhibitors to Factor VIII (because Recombinate may not work for you).
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults and children: Your healthcare provider will prescribe the appropriate dose for you or your child, based on the type of surgery or condition being treated.
Use Recombinate exactly as prescribed by your healthcare provider. Do not use it more often or stop using it without first talking to your healthcare provider.
After reconstituting, administer Recombinate within 3 hours. Do not refrigerate after reconstituting.
Please review the instructions from your healthcare provider regarding how to properly administer Recombinate. It is recommended to use the administration set provided.
Do not attempt to self-infuse Recombinate unless you have been taught how by your healthcare provider or hemophilia center.
No significant interactions have reported with Recombinate at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.
The effects of Recombinate during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
Recombinate should be used under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.
Store in the refrigerator or at room temperature. Do not freeze.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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