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  • Generic Name: (tretinoin)
    Other Brands: N/A
  • Last Revised: 05/2014
    • What is this medication and its most common uses?

      Refissa is a topical medicine (applied directly on the skin) used to reduce fine facial wrinkles or improve changes in your facial skin color or facial roughness in people who are using a total skin care and sunlight avoidance program. Refissa is available as a cream.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Refissa is thought to work by enhancing the peeling of skin, and by slowing down the way the body removes skin cells that may be harmed by the sun.

      Refissa does not remove wrinkles, repair sun-damaged skin, reverse aging caused by the sun, or restore more youthful or younger skin.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: In studies, more than 60% of people treated with Refissa found their fine wrinkles to be less apparent after 24 weeks of treatment.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you use Refissa exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may start to notice an improvement in the appearance of your skin after starting treatment with Refissa. This is a good indicator that your medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Common side effects may include: peeling, dry skin, burning, stinging, redness, itching.

    • Who should not take this medication?

      Do not use Refissa if you are allergic to it or any of its ingredients.

      Do not use Refissa if you are pregnant or plan to become pregnant.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Refissa. Also, talk to your healthcare provider about your complete medical history, especially if you have eczema (an inflammation or irritation of the skin), sunburned skin, are sensitive to sunlight, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Apply a small, pea-sized amount to your face once a day, in the evening.

    • How should I take this medication?

      Use Refissa exactly as prescribed by your healthcare provider. Do not use it more often or stop using it without first talking to your healthcare provider.

      Gently wash your face with a mild soap, pat your skin dry, and wait 20 to 30 minutes before applying Refissa.

      You may feel warmth or slight stinging after you apply Refissa. This is temporary.

    • What should I avoid while taking this medication?

      Do not become pregnant while you are using Refissa.

      Do not expose your skin to excessive sunlight and ultraviolet lights (such as sunlamps or tanning beds) while using Refissa. Use a daily sunscreen and protective clothing to protect your skin from sunlight.

      Do not expose your skin to extreme cold weather and wind.

      Do not use skin products that can dry or irritate your skin.

      Do not get Refissa in your eyes, ears, nostrils, angles of your nose, or mouth.

    • What are the possible food and drug interactions associated with this medication?

      If Refissa is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Refissa with the following: medicated soaps or skin cleansers; medicines that increase your sensitivity to sunlight (such as hydrochlorothiazide, doxycycline, ciprofloxacin, chlorpromazine, or sulfamethoxazole); or products that contain alcohol, astringents, or spices.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Refissa during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Refissa, apply it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not apply two doses at once.

    • How should I store this medication?

      Store at room temperature. Do not freeze.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.